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However, their petrochemical origin and adverse health effects, particularly xeno\u2010oestrogenic activity, pose a challenge for sustainability and have been almost banned globally. Herein, we report a novel bio\u2010based cyclohexyl fatty alcohol ethoxylates (CyCC\n                    <jats:italic>\n                      <jats:sub>n<\/jats:sub>\n                    <\/jats:italic>\n                    E\n                    <jats:sub>9<\/jats:sub>\n                    ) by applying molecular segments reorganization strategy and retrosynthetic analysis method. By constructing acid\u2010base bifunctional Zn\u2010based single\u2010atom catalyst, we achieved efficient synthesis of CyCC\n                    <jats:italic>\n                      <jats:sub>n<\/jats:sub>\n                    <\/jats:italic>\n                    E\n                    <jats:sub>9<\/jats:sub>\n                    . These bio\u2010based CyCC\n                    <jats:italic>\n                      <jats:sub>n<\/jats:sub>\n                    <\/jats:italic>\n                    E\n                    <jats:sub>9<\/jats:sub>\n                    displayed outstanding defoaming ability, super\u2010wettability, and better emulsification ability. More excitingly, the primary degradation products of CyCC\n                    <jats:italic>\n                      <jats:sub>n<\/jats:sub>\n                    <\/jats:italic>\n                    E\n                    <jats:sub>9<\/jats:sub>\n                    demonstrated markedly reduced toxicity toward zebrafish embryos and larvae, suggesting superior biocompatibility. The CyCC\n                    <jats:italic>\n                      <jats:sub>n<\/jats:sub>\n                    <\/jats:italic>\n                    E\n                    <jats:sub>9<\/jats:sub>\n                    showed excellent low\u2010temperature cleaning performance toward stains of various metallic surfaces. This work paves new ways to create sustainable alternative of alkylphenol ethoxylates using renewable biomass resources, as well as provide inspiring insights for the transformative revolution of other petroleum\u2010based restricted products.\n                  <\/jats:p>","DOI":"10.1002\/anie.2280699","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:44:34Z","timestamp":1785941074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Segments Reorganization Strategy Coupled With Retrosynthetic Analysis for Designing Sustainable Alternatives to Alkylphenol Ethoxylates"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8141-7401","authenticated-orcid":false,"given":"Lining","family":"Bao","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Shanxi Key Laboratory of Chemical Product Engineering Taiyuan University of Technology  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Shanxi Key Laboratory of Chemical Product Engineering Taiyuan University of Technology  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitao","family":"Yue","sequence":"additional","affiliation":[{"name":"College of Environment and Resource Research Center of Environment and Health Shanxi University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexiang","family":"Bi","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Shanxi Key Laboratory of Chemical Product Engineering Taiyuan University of Technology  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-732X","authenticated-orcid":false,"given":"Xu","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Shanxi Key Laboratory of Chemical Product Engineering Taiyuan University of Technology  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yun","sequence":"additional","affiliation":[{"name":"College of Environment and Resource Research Center of Environment and Health Shanxi University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2433-3200","authenticated-orcid":false,"given":"Nan","family":"Sang","sequence":"additional","affiliation":[{"name":"College of Environment and Resource Research Center of Environment and Health Shanxi University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5623-3514","authenticated-orcid":false,"given":"Jinxiang","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Shanxi Key Laboratory of Chemical Product Engineering Taiyuan University of Technology  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh0993"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202312823"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2025.103471"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001720\u20103"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893\u2010024\u201001464\u2010x"},{"key":"e_1_2_8_7_1","volume-title":"Environmental and human Safety of Major Surfactants: Alcohol Ethoxylates and Alkylphenol Ethoxylate","author":"Talmage S. 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