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The challenge for the exploration of highly potent CDs is to circumvent the severe thermodynamic and kinetic paradox to transform surrounding substrates into ultra\u2010reactive ROS. To address this conundrum, we propose a long\u2010pathway electron\u2010accepting strategy promoting the absolute spatial charge decoupling by the elaborate marriage of carbonized core and polynaphthalenediimide (PNDI) network, which significantly boosts the superoxide anion (\u00b7O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and hydroxyl radical (\u00b7OH) dual\u2010ROS generation of the constructed polymer CDs. Systematic mechanism exploration reveals that ultrafast intramolecular charge transfer after photoirradiation enables energetic long\u2010life electrons to migrate along the PNDI highway for abundant \u00b7O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    production. Intriguingly, this profound separation firmly anchors uncompensated highly oxidative holes at the extraordinarily deep highest occupied molecular orbital level of the carbon core, successfully unlocking the thermodynamic threshold for direct \u00b7OH generation. This tailored dual\u2010ROS storm induces catastrophic EPS matrix degradation and massacres the embedded pathogens, achieving near\u2010complete (\u223c99.9%) eradication of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    biofilms. This work establishes a potent nanoplatform and provides profound mechanistic insights for tackling global biofilm\u2010associated threats.\n                  <\/jats:p>","DOI":"10.1002\/anie.2382848","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:09:32Z","timestamp":1780470572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deciphering Augmented Dual\u2010ROS\u2010Driven Biofilm Eradication by Facilitating Long\u2010Range Spatial Charge Decoupling in Polymer Carbon Dots"],"prefix":"10.1002","volume":"65","author":[{"given":"Shujing","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Rong","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu 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