{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:50:05Z","timestamp":1791622205759,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52573172"],"award-info":[{"award-number":["52573172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231523"],"award-info":[{"award-number":["BK20231523"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["SBK2024047584"],"award-info":[{"award-number":["SBK2024047584"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Phototheranostic agents operating in the second near\u2010infrared (NIR\u2010II) window hold great potential for precision cancer therapy, yet the rational regulation of excited\u2010state processes to simultaneously optimize fluorescence and phototherapeutic performances remains a fundamental challenge. Herein, we report a topology\u2010driven excited\u2010state engineering strategy for constructing conjugated oligomers with tailored excited\u2010state manifolds and multi\u2010channel excitation dynamics. By precisely manipulating molecular topology, conjugated topological oligomers achieve enhanced light\u2010harvesting capability and optimized exciton utilization, thereby enabling synergistic regulation of excitation dynamics. Under 808\u00a0nm laser irradiation, nanoparticles (NPs) derived from TBT\u20103 exhibit 2.8\u2010fold enhanced NIR\u2010II fluorescence brightness, 2.7\u2010fold improved photothermal performance, and 7.5\u2010fold increased total reactive oxygen species (ROS) generation compared with TBT\u20101. In vivo studies demonstrate that TBT\u20103 NPs enable high\u2010resolution NIR\u2010II fluorescence imaging and efficient tumor elimination. Moreover, TBT\u20103\u2010mediated phototherapy induces immunogenic cell death and enhances antitumor immunity, leading to improved therapeutic efficacy when combined with anti\u2010PD\u20101 immune checkpoint blockade. This work provides a molecular topology\u2010based strategy for manipulating excited\u2010state landscapes and establishes conjugated oligomers as versatile candidates for NIR\u2010II phototheranostics and cancer immunotherapy.<\/jats:p>","DOI":"10.1002\/anie.2484646","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:38:42Z","timestamp":1791621522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topological Engineering of NIR\u2010II Emissive Conjugated Oligomers With Unexpected Excited\u2010State Manifolds for Efficient Phototheranostics and Cancer Immunotherapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6460-8976","authenticated-orcid":false,"given":"Yuliang","family":"Yang","sequence":"first","affiliation":[{"name":"The Fourth Affiliated Hospital of Soochow University, College of Pharmaceutical Sciences Suzhou Medical College Soochow University Suzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3683-4290","authenticated-orcid":false,"given":"Yijian","family":"Gao","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Soochow University, College of Pharmaceutical Sciences Suzhou Medical College Soochow University Suzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-5898","authenticated-orcid":false,"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Soochow University, College of Pharmaceutical Sciences Suzhou Medical College Soochow University Suzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-9424","authenticated-orcid":false,"given":"Yingpeng","family":"Wan","sequence":"additional","affiliation":[{"name":"Center of Super\u2010Diamond and Advanced Films (COSDAF) Department of Chemistry City University of Hong Kong  Kowloon Hong Kong SAR P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-3399","authenticated-orcid":false,"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Super\u2010Diamond and Advanced Films (COSDAF) Department of Chemistry City University of Hong Kong  Kowloon Hong Kong SAR P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8685-7412","authenticated-orcid":false,"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Soochow University, College of Pharmaceutical Sciences Suzhou Medical College Soochow University Suzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0405-5455","authenticated-orcid":false,"given":"Cui","family":"Cen","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Soochow University, College of Pharmaceutical Sciences Suzhou Medical College Soochow University Suzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Soochow University, College of Pharmaceutical Sciences Suzhou Medical College Soochow University Suzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3890-8482","authenticated-orcid":false,"given":"Shengliang","family":"Li","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Soochow University, College of Pharmaceutical Sciences Suzhou Medical College Soochow University Suzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010021\u201000326\u2010w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CS00599J"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002140\u2010y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002536\u2010w"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202306492"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202307776"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00001H"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010024\u201000892\u20100"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202007040"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001501\u20104"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c14887"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050202\u20106"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00671H"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010024\u201000196\u2010z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001422\u20102"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00664E"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00173B"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001242\u2010w"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201075247\u20107"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023194\u2010w"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202501919"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c12430"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010025\u201001851\u20107"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41566\u2010022\u201001106\u20108"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310032"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202511731"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c12316"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx4850"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046853\u20100"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202510386"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202001146"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801216"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010024\u201001275\u20107"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055096\u2010y"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042691\u20108"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003399"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160\u2010025\u201000921\u20105"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41566\u2010022\u201001092\u2010x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202419785"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c15150"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.73793"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.8399023"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.2464659"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.5995290"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c16139"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202414542"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c01473"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010024\u201000704\u2010y"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010025\u201000343\u20100"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050020\u2010w"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006987\u20105"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201049394\u20108"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c10277"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202513693"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.70200"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202524131"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010025\u201002309\u20104"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.2484646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.2484646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.2484646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:38:50Z","timestamp":1791621530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.2484646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":57,"alternative-id":["10.1002\/anie.2484646"],"URL":"https:\/\/doi.org\/10.1002\/anie.2484646","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,10]]},"assertion":[{"value":"2026-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2484646"}}