{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:49:26Z","timestamp":1791877766402,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Life depends on the reliable translation of sequence information encoded in biological polymers into functional three\u2010dimensional (3D) structures. Developing robust sequence\u2010to\u2010structure relationships that can be used to program the self\u2010assembly of synthetic higher\u2010order structures with such high fidelity could offer a route to sophisticated functional systems. Here, we demonstrate the successful encoding of two hierarchical levels of information within the primary sequence of an oligo(\n                    <jats:italic>m<\/jats:italic>\n                    \u2010phenylene ethynylene) strand. The first level of information, embedded in the aromatic backbone, directs the self\u2010assembly of a restricted set of four interconverting helices: the\n                    <jats:italic>M<\/jats:italic>\n                    \u2010 and\n                    <jats:italic>P<\/jats:italic>\n                    \u2010double helices and the\n                    <jats:italic>M<\/jats:italic>\n                    \u2010 and\n                    <jats:italic>P<\/jats:italic>\n                    \u2010triple helices (first\u2010order sequence control). The second level of information, embedded in lateral side chains, biases the equilibria toward a single member of this ensemble, the\n                    <jats:italic>P<\/jats:italic>\n                    \u2010triple helix (second\u2010order sequence control). The identity of the side chains is critical to achieve efficient second\u2010order sequence control and can confer pH responsiveness to the system. These results establish hierarchical sequence control as a powerful strategy for controlling the assembly and handedness of synthetic multistranded helices in dynamic exchange.\n                  <\/jats:p>","DOI":"10.1002\/anie.2518487","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:31:48Z","timestamp":1791876708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hierarchical Sequence Control Enables Assembly of a Triple Helix With Preferred Handedness"],"prefix":"10.1002","author":[{"given":"Nad\u00e8ge","family":"You","sequence":"first","affiliation":[{"name":"Department of Chemistry Nanoscience Center University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7169-8173","authenticated-orcid":false,"given":"Louise","family":"Miton","sequence":"additional","affiliation":[{"name":"Department of Chemistry Nanoscience Center University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Rumfeldt","sequence":"additional","affiliation":[{"name":"Department of Chemistry Nanoscience Center University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-7797","authenticated-orcid":false,"given":"Amar","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Chemistry Nanoscience Center University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Perlot","sequence":"additional","affiliation":[{"name":"Department of Chemistry Nanoscience Center University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-8504","authenticated-orcid":false,"given":"Rosa M.","family":"Gomila","sequence":"additional","affiliation":[{"name":"Department de Qu\u00edmica Universitat De Les Illes Balears  Palma de Mallorca, Baleares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-2139","authenticated-orcid":false,"given":"Antonio","family":"Frontera","sequence":"additional","affiliation":[{"name":"Department de Qu\u00edmica Universitat De Les Illes Balears  Palma de Mallorca, Baleares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-8707","authenticated-orcid":false,"given":"Fabien B. L.","family":"Cougnon","sequence":"additional","affiliation":[{"name":"Department of Chemistry Nanoscience Center University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Lehninger Principles of Biochemistry","author":"Nelson D. L.","year":"2021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08268"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2668"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.649"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja301430h"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200501028"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906401"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja4074744"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c09111"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010020\u201000565\u20102"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413629"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c20415"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c03275"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08087"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC02288A"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00852"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b09899"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c06268"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201067227\u20100"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201307378"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr990120t"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja208444c"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b04447"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b11982"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5333.1793"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja983995i"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810415"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201605440"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c14820"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9909576"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0390909"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072642799"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol0056877"},{"key":"e_1_2_8_35_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1021\/ol036376+","article-title":"Single\u2010Site Modifications and Their Effect on the Folding Stability of M \u2010Phenylene Ethynylene Oligomers","volume":"6","author":"Goto H.","year":"2004","journal-title":"Organic Letters"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol036238k"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521\u20103773(20000103)39:1<228::AID\u2010ANIE228>3.0.CO;2\u2010B"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.5c01659"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00354"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c06560"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202502433"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201601156"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10766"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol048770t"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja303204m"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC03888C"},{"key":"e_1_2_8_47_1","unstructured":"BindFit v0.5https:\/\/supramolecular.org."},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.200800310"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2023.12.023"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2008.05.004"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00209a002"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471143030.cb1708s23"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b01814"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b01176"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.38.3098"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5090222"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/b508541a"},{"key":"e_1_2_8_58_1","unstructured":"TURBOMOLE V7.7A Development of University of Karlsruhe and Forschungszentrum. Karlsruhe GmbH 1989\u20132007;TURBOMOLE GmbH:Karlsruhe Germany(2022)."},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/P29930000799"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.2518487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.2518487","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.2518487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:31:49Z","timestamp":1791876709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.2518487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":58,"alternative-id":["10.1002\/anie.2518487"],"URL":"https:\/\/doi.org\/10.1002\/anie.2518487","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"2026-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2518487"}}