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Herein, we attempt to redefine the functionality of PSs through a consensus\u2010assisted design strategy that integrates deep learning and molecular docking to embed orthogonal antibacterial mechanisms into a single PS molecule. Specifically, a near\u2010infrared hemi\u2010cyanine PS IHcy\u2010OH is found to unite PDAT with interference of filamentous temperature\u2010sensitive mutant Z (FtsZ) protein, which is essential for bacterial division. By conjugating IHcy\u2010OH with a responsive arm, IHcy\u2010PbE is rationally designed and synthesized to achieve infection responsiveness, rapid light\u2010controlled bactericidal activity, and long\u2010time bacterial inhibition. While such integration typically requires complex multi\u2010component platforms, this strategy successfully unlocks the multifunctional potential of a single PS molecule. Consistent with its design, IHcy\u2010PbE could inhibit methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (MRSA) in the dark and exert robust PDAT efficacy upon exposure to hydrogen peroxide and light. This work helps to transform PSs from ROS\u2010dependent killing agents into therapeutics with orthogonal antibacterial mechanisms, establishing a proof\u2010of\u2010concept for a generalizable PSs design paradigm.\n                  <\/jats:p>","DOI":"10.1002\/anie.2546246","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:05:51Z","timestamp":1789527951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Redefining Photosensitizers Functionality Through Consensus\u2010Assisted Integration of Orthogonal Antibacterial Mechanisms"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4498-0609","authenticated-orcid":false,"given":"Wenlin","family":"Cai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian P. R. 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