{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:49:00Z","timestamp":1791650940112,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22577156"],"award-info":[{"award-number":["22577156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22377147"],"award-info":[{"award-number":["22377147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2632026ZD14"],"award-info":[{"award-number":["2632026ZD14"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Reactive sulfur species derived from hydrogen sulfide are central regulators of redox signaling; however, sulfenic acid (HSOH) has remained largely inaccessible owing to the absence of chemically defined donor systems. Here we report a mechanistically delineated strategy for controlled HSOH generation based on an intramolecular cyclization\u2013release platform incorporating an aminosulfine (thioamide S\u2010oxide) motif. Aminosulfine derivatives containing an ester group can undergo a unique acyl transfer process via the nucleophilicity of the \u03b1\u2010amide ion, followed by intramolecular cyclization to release HSOH, providing a chemically tractable route for transient HSOH release. Systematic structure\u2013activity relationship and kinetic studies further indicate that achieving efficient HSOH release requires precise kinetic matching between the acyl transfer rate and the intramolecular cyclization rate. Using complementary chemical trapping approaches and a persulfide\u2010selective fluorescent probe, we demonstrate that transiently generated HSOH exhibits exceptionally high reactivity, rapidly undergoing disproportionation and efficiently promoting thiol persulfidation even at low concentrations. Importantly, HSOH signaling confers protection against oxidative injury in a cellular oxygen\u2013glucose deprivation model. This work establishes a chemically defined framework for probing HSOH\u2010initiated sulfur signaling and provides fundamental insights into the reactivity and biological implications of this elusive reactive sulfur species.<\/jats:p>","DOI":"10.1002\/anie.2643229","type":"journal-article","created":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:46:36Z","timestamp":1787507196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aminosulfine\u2010Based Donor Platform for Controlled Release of Sulfenic Acid (HSOH)"],"prefix":"10.1002","volume":"65","author":[{"given":"Jianru","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines Center of Drug Discovery China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ethnic Medicine Resource Chemistry Ministry of Education Yunnan Minzu University  Kunming Yunnan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xidan","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Center of Drug Discovery China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Key Laboratory of Drug Metabolism and Pharmacokinetics China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3158-3162","authenticated-orcid":false,"given":"Qiwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Center of Drug Discovery China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Center of Drug Discovery China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Center of Drug Discovery China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0387-7097","authenticated-orcid":false,"given":"Weiwei","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Science China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8912-6044","authenticated-orcid":false,"given":"Yueqin","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines Center of Drug Discovery China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4433"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5869"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14330"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01311-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00205"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201704117"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09795"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c03565"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02454"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c11540"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201802845"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c05874"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07225"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202502917"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c12908"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202201668"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202014052"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302303"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202010530"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202422087"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08469"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202512610"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202314563"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.10.012"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2614(94)00293-2"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200305192"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2016.09.018"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00545a008"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.434294"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/194081a0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46652-7"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c00196"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)61689-1"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)02033-4"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/17415993.2020.1727905"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1980.619"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC02569A"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2026.01.044"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c03627"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00781a029"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00145a008"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.1c00164"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.01.023"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.2643229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.2643229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.2643229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:50:35Z","timestamp":1791647435000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.2643229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,23]]},"references-count":44,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2026,10,12]]}},"alternative-id":["10.1002\/anie.2643229"],"URL":"https:\/\/doi.org\/10.1002\/anie.2643229","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,23]]},"assertion":[{"value":"2026-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2643229"}}