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Here, we report a neutrophil extracellular traps (NETs)\u2010mimetic, dopamine\u2010incorporated DNA net, termed D\n                    <jats:sup>A<\/jats:sup>\n                    Net\u2010DA, enabling targeted bacterial eradication and concurrent toxin neutralization. Inspired by the trap\u2010kill\u2010neutralize function of NETs, D\n                    <jats:sup>A<\/jats:sup>\n                    Net\u2010DA selectively captures and traps bacteria, followed by in situ catalytic formation of polydopamine nanoshells on the trapped bacteria. This process enables efficient photothermal bacterial eradication while minimizing damage to host cells. Meanwhile, the nanoshells act as molecular sponges to sequester and neutralize bacterial toxins, thereby mitigating toxin\u2010associated inflammation. These integrated functions endow D\n                    <jats:sup>A<\/jats:sup>\n                    Net\u2010DA with potent therapeutic efficacy in vivo, as demonstrated by markedly reduced bacterial burdens, toxin levels, tissue inflammation in both conventional and burn wound infection models. Moreover, the simultaneous clearance of bacteria and residual toxins alleviates pro\u2010inflammatory macrophage polarization, thereby accelerating wound tissue regeneration. This work presents a NETs\u2010mimetic antibacterial strategy that integrates pathogen clearance with toxin neutralization, offering a promising method for treating bacterial infection\u2010associated diseases.\n                  <\/jats:p>","DOI":"10.1002\/anie.2705500","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:37:06Z","timestamp":1791686226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil Extracellular Trap\u2010Mimetic DNA Nets Enable Concurrent Bacteria\u2010Targeted Eradication and Toxin Neutralization"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8868-0699","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"first","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu 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