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Their structures with absolute configurations were established using comprehensive spectroscopic analyses that were supported by computational calculations. Biosynthetic considerations suggest that\n                    <jats:bold>1<\/jats:bold>\n                    \u2212\n                    <jats:bold>7<\/jats:bold>\n                    could be derived from a single precursor\n                    <jats:bold>8<\/jats:bold>\n                    . Guided by this insight, a bioinspired synthesis of\n                    <jats:bold>1<\/jats:bold>\n                    \u2212\n                    <jats:bold>7<\/jats:bold>\n                    was achieved in a total of 7\u22129 steps from\n                    <jats:bold>8<\/jats:bold>\n                    . The synthesis is enabled by bioinspired cascade reactions encompassing oxidative rearrangement, Michael additions, hemiketalizations, 6\u03c0\u2010electrocyclization, and hetero\u2010Diels\u2013Alder reaction. Notably, congener\n                    <jats:bold>2<\/jats:bold>\n                    exhibited anti\u2010ischemic stroke activity both in vitro and in vivo, suggesting its potential as a neuroprotective candidate for further therapeutic evaluation.\n                  <\/jats:p>","DOI":"10.1002\/anie.2810612","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:37:01Z","timestamp":1790314621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery and Bioinspired Synthesis of Neuroprotective Geranylated Chalcones From\n                    <i>Artocarpus communis<\/i>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0166-4426","authenticated-orcid":false,"given":"Rui\u2010Li","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence 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