{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:44:33Z","timestamp":1791873873175,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Precise regulation over the dimensionality and topology of covalent organic frameworks (COFs) through metal coordination remains a fundamental challenge. Herein, we report an in situ metal\u2010chelation strategy for topology regulation and single\u2010site construction in COFs using a bifunctional\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010hydroxy ketone\u2010functionalized HDBC monomer. Metal\u2010free Schiff\u2010base condensation of HDBC with TAPy affords a one\u2010dimensional covalent ribbon framework, named COF\u2010HDBC. Strikingly, in situ Cu\n                    <jats:sup>2+<\/jats:sup>\n                    chelation during solvothermal crystallization redirects the assembly pathway toward a two\u2010dimensional\n                    <jats:italic>bex<\/jats:italic>\n                    \u2010type Cu\u2010COF\u2010HDBC containing framework\u2010embedded Cu\u2500O coordination sites. Post\u2010synthetic metalation of preassembled COF\u2010HDBC fails to trigger this transformation, verifying the indispensable structure\u2010directing effect of in situ chelation during nucleation and growth. This strategy is extendable to Ni\n                    <jats:sup>2+<\/jats:sup>\n                    and Co\n                    <jats:sup>2+<\/jats:sup>\n                    , affording isostructural metal\u2010chelated COFs. Multiscale characterizations and Cu K\u2010edge XAFS collectively support the proposed framework structures and the predominantly isolated nature of the Cu centers. As a functional validation, Cu\u2010COF\u2010HDBC enables selective CO\n                    <jats:sub>2<\/jats:sub>\n                    \/CO electroreduction to CH\n                    <jats:sub>4<\/jats:sub>\n                    . This work establishes in situ metal chelation as a synthetic handle for programming COF topology and constructing framework\u2010embedded single\u2010metal sites, offering a versatile route to crystalline porous materials with complex architectures and tunable functions.\n                  <\/jats:p>","DOI":"10.1002\/anie.2910902","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:45:36Z","timestamp":1791870336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Situ Metal Chelation for Topology Regulation and Single\u2010Site Construction in Covalent Organic Frameworks"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0432-7045","authenticated-orcid":false,"given":"Xiang\u2010Hao","family":"Han","sequence":"first","affiliation":[{"name":"Department of Physics and Materials The Hong Kong Polytechnic University Kowloon Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Physics City University of Hong Kong  Kowloon Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-5033","authenticated-orcid":false,"given":"Kai","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Physics and Materials The Hong Kong Polytechnic University Kowloon Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1491-743X","authenticated-orcid":false,"given":"Kian Ping","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Chemistry National 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