{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:41:06Z","timestamp":1792262466147,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"43","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PID2023\u2010152131NB\u2010I00"],"award-info":[{"award-number":["PID2023\u2010152131NB\u2010I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,10,19]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Three\u2010dimensional, conformationally rigid molecular architectures are increasingly valued in chemical biology and drug discovery, yet their syntheses often rely on step\u2010intensive or metal\u2010mediated methods. Herein, we report a metal\u2010free, redox\u2010neutral photocatalytic approach that enables otherwise challenging divergent [3+2\u03c0\/\u03c3] photocycloadditions of nitrones under mild conditions. Visible\u2010light excitation of an acridinium photocatalyst promotes cycloaddition of nitrones with alkynes to furnish densely substituted 4\u2010isoxazolines, prototypical \u201cFlatland\u201d heterocycles, while engagement of bicyclo[1.1.0]butanes triggers rapid skeletal reorganization to deliver oxa\u2013aza\u2013bicycloheptanes that escape flatland into three\u2010dimensional chemical space. Both product classes are synthetically challenging under conventional thermal or metal\u2010catalyzed conditions. The transformation tolerates a wide range of functional groups and provides access to bioisosterically relevant structural motifs. Synthetic photocatalysis is typically designed around thermodynamic considerations, yet the role of electron transfer kinetics in controlling reactivity remains underdeveloped. We establish kinetic electron transfer gating as a general design principle whereby substrate assembly directs charge transfer toward otherwise disfavoured partners, overriding thermodynamic preferences. Mechanistic investigations, in conjunction with density functional theory (DFT) calculations, support a unified photocatalytic manifold and clarify the origin of the divergent reactivity, thereby providing a platform for various downstream transformations.<\/jats:p>","DOI":"10.1002\/anie.2936884","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:20:23Z","timestamp":1787851223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A\n                    <i>d<\/i>\n                    <i>e<\/i>\n                    \u2010\n                    <i>n<\/i>\n                    <i>ovo<\/i>\n                    Approach Towards Divergent [3+2\u03c0\/\u03c3] Photocycloadditions of Nitrones via Assembly\u2010Controlled Kinetic Electron Transfer Gating"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1688-8637","authenticated-orcid":false,"given":"Nayan","family":"Saha","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry and Pharmacy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9379-7535","authenticated-orcid":false,"given":"Rajesh","family":"Kancherla","sequence":"additional","affiliation":[{"name":"KAUST Catalysis Center (KCC) King Abdullah University of Science and Technology (KAUST)  Thuwal Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6756-0991","authenticated-orcid":false,"given":"Jorge","family":"Escorihuela","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Faculty of Pharmacy and Food Sciences Universitat De Val\u00e8ncia  Burjassot Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana","family":"Chandran","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry and Pharmacy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-6841","authenticated-orcid":false,"given":"Mrinal K.","family":"Bera","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Engineering Science and Technology (IIEST), Shibpur  Howrah West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4580-5227","authenticated-orcid":false,"given":"Magnus","family":"Rueping","sequence":"additional","affiliation":[{"name":"KAUST Catalysis Center (KCC) King Abdullah University of Science and Technology (KAUST)  Thuwal Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-4850","authenticated-orcid":false,"given":"Burkhard","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry and Pharmacy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA06028A"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.201800024"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00449"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202403824"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c09612"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010018\u20102152\u20106"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9010803"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm2010404"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2014.940932"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201002065"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3GC00557G"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01528a060"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05290-z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-022-00811-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202300008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00473"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00915"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c04403"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010024\u201001239\u20109"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001135\u2010y"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02976"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413695"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05304"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c03248"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c13080"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01610"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4017625"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2010.11.014"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010023\u201003073\u20103"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201804225"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC03948F"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB02812E"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202304246"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202506747"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.70261"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426\u2010025\u20102941\u20102"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.70194"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.70007"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.70244"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b01499"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b03369"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202500630"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0OB02158J"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b02251"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310671"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318476"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c10123"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201052419\u2010x"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.4c00839"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c12894"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/1010\u20106030(91)85056\u2010M"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr60230a006"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja506228u"},{"key":"e_1_2_8_55_1","unstructured":"M. J.Frisch G. W.Trucks H. B.Schlegel et\u00a0al. Gaussian 16 Revision B.01 (2016) https:\/\/gaussian.com\/citation\/."},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.22885"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.2936884","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.2936884","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.2936884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:42:48Z","timestamp":1792258968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.2936884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":55,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2026,10,19]]}},"alternative-id":["10.1002\/anie.2936884"],"URL":"https:\/\/doi.org\/10.1002\/anie.2936884","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"2026-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2936884"}}