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However, access to\n                    <jats:italic>S<\/jats:italic>\n                    \u2010stereogenic \u03b1\u2010fluoroalkyl S(IV\/VI) compounds still relies largely on classical resolution, resulting in limited efficiency and selectivity. We herein report a copper\u2010catalyzed asymmetric radical C\u2013S cross\u2010coupling that effectively tames highly reactive \u03b1\u2010fluoroalkyl radicals, enabled by a sequential stereodiscrimination\u2013chirality transfer strategy, providing rapid access to\n                    <jats:italic>S<\/jats:italic>\n                    \u2010chiral \u03b1\u2010fluoroalkyl sulfilimines. Integrated with downstream transformations, this reaction serves as a general and systematic platform for\n                    <jats:italic>S<\/jats:italic>\n                    \u2010chiral \u03b1\u2010fluoroalkyl S(IV\/VI) compounds. The synthetic utility of the method is demonstrated by gram\u2010scale synthesis and concise access to diverse chiral fluoroalkyl reagents and bioisosteres of sulfur\u2010containing drugs.\n                  <\/jats:p>","DOI":"10.1002\/anie.3129452","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T18:56:41Z","timestamp":1781290601000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A General Platform for\n                    <i>S<\/i>\n                    \u2010Stereogenic \u03b1\u2010Fluoroalkyl S(IV\/VI) Compounds via Enantioselective Radical Fluoroalkylation of Sulfenamides"],"prefix":"10.1002","volume":"65","author":[{"given":"Yu\u2010Shuai","family":"Zhang","sequence":"first","affiliation":[{"name":"New Cornerstone Science Laboratory Shenzhen Grubbs Institute Department of Chemistry and Guangming Advanced Research Institute Southern University of Science and Technology  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