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The transformation proceeds under very mild conditions and high chemoselectivity, favoring C\u2500C over C\u2500H insertion pathways. In a single step, two C(sp\n                    <jats:sup>2<\/jats:sup>\n                    )\u2500C(sp\n                    <jats:sup>3<\/jats:sup>\n                    ) bonds are formed, granting access to homologated imines bearing a newly constructed quaternary carbon center in good yields. Subsequent hydrolysis gave homologated aldehydes, enabling versatile downstream transformations. The diazo intermediate is generated using a continuous\u2010flow microreactor, enhancing both safety and scalability. Mechanistic insights, supported by density functional theory (DFT) calculations, reveal the origins of the observed selectivity and reactivity.\n                  <\/jats:p>","DOI":"10.1002\/anie.3147869","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:25:36Z","timestamp":1790425536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aza\u2010B\u00fcchner\u2013Curtius\u2013Schlotterbeck Reaction Enables Selective Construction of Quaternary Carbon Centers"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4443-1215","authenticated-orcid":false,"given":"Simon O.","family":"Angerer","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry and Pharmacy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-895X","authenticated-orcid":false,"given":"Vincent","family":"George","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry and Pharmacy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryaman","family":"Pattanik","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry and Pharmacy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9675-5582","authenticated-orcid":false,"given":"Gaia","family":"Carpentiero","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry and Pharmacy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Morcinkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry and Pharmacy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Rehbein","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry and Pharmacy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-4850","authenticated-orcid":false,"given":"Burkhard","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry and Pharmacy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2016.09.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00829"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03193"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901241e"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20347b"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00590"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.6.1504S"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"14905","DOI":"10.1021\/jacs.4c15827","article-title":"Aryl Acid\u2010Alcohol Cross\u2010Coupling: C(sp3)\u2500C(sp2) Bond Formation From Nontraditional Precursors","volume":"147","author":"Lin E.","year":"2025","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19280610634"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.188501802118"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202211578"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC03581F"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00275a006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104039(00)01856\u20106"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00127a008"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo030360f"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/9780470638859.conrr124","volume-title":"Comprehensive Organic Name Reactions and Reagents","author":"Wang Z.","year":"2010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00381"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1039\/jr9620001232","article-title":"237. 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