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In contrast, a concept of a gas\u2010mediated redox process may offer unique advantages, including its facile removal from the reaction medium. However, such a concept has remained unknown. Addressing this gap, we report the use of the SO\n                    <jats:sub>2<\/jats:sub>\n                    gas molecule as an electron\u2010transfer mediator by generating the sulfur dioxide radical anion (SO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    ) under ambient and chemical conditions. Such SO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    enabled chemoselective, controlled, and scalable multi\u2010electron reductions (2e\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/2H\n                    <jats:sup>+<\/jats:sup>\n                    , 4e\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/4H\n                    <jats:sup>+<\/jats:sup>\n                    , 6e\n                    <jats:sup>\u2212<\/jats:sup>\n                    \/6H\n                    <jats:sup>+<\/jats:sup>\n                    ) of diverse nitrogen\u2010containing substrates. Furthermore, the method was successfully applied to the synthesis of clinically active drugs on a multi\u2010gram scale. Therefore, this work establishes a new paradigm in redox chemistry, demonstrating that a gas molecule can act as an electron\u2010transfer catalyst, capable of performing reactions that typically require transition metals.\n                  <\/jats:p>","DOI":"10.1002\/anie.3181079","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T07:47:17Z","timestamp":1787816837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SO\n                    <sub>2<\/sub>\n                    \u2010Mediated 2e\n                    <sup>\u2212<\/sup>\n                    , 4e\n                    <sup>\u2212<\/sup>\n                    , and 6e\n                    <sup>\u2212<\/sup>\n                    Reductions: Facile Access to Aryl Amines"],"prefix":"10.1002","volume":"65","author":[{"given":"Partha Protim","family":"Dey","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences Indian Institute of Science Education and Research  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramita","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences Indian Institute of Science Education and Research  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallabi","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences Indian Institute of Science Education and Research  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-7886","authenticated-orcid":false,"given":"Anex","family":"Jose","sequence":"additional","affiliation":[{"name":"The Advanced Light Source Lawrence Berkeley National Laboratory  Berkeley California 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