{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:54:25Z","timestamp":1790873665770,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS\u20102025\u201025442707"],"award-info":[{"award-number":["RS\u20102025\u201025442707"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report an unprecedented, highly general organic photocatalytic strategy for direct C(sp\n                    <jats:sup>2<\/jats:sup>\n                    )\u2013H amination of arenes using easily accessible saccharin as a nitrogen source. In sharp contrast to conventional radical amination protocols requiring transient arene radical cation intermediates, our system operates via an initial preferential single\u2010electron transfer (SET) oxidation of the in situ\u2013generated saccharinate anion. This mechanistic pivot successfully bypasses longstanding electronic limitations, enabling an exceptionally broad substrate scope. The protocol tolerates a full spectrum of aromatic systems, including unactivated benzene (using only 2.0 equiv), haloarenes, polycyclic networks, highly electron\u2010deficient arenes bearing strong electron\u2010withdrawing groups (ester, nitrile, or trifluoromethyl substituents), and complex pharmaceutical frameworks, delivering the corresponding\n                    <jats:italic>N<\/jats:italic>\n                    \u2010aryl saccharins in up to 99% yield (98% for benzene) with predictable regioselectivity. Density functional theory (DFT) calculations quantitatively corroborate the electrophilic radical kinetics (\u0394\n                    <jats:italic>G<\/jats:italic>\n                    <jats:sup>\u2021<\/jats:sup>\n                    = 2.3\u201314.4\u00a0kcal\/mol for arene addition) and TEMPO\u2010mediated rearomatization cascade. Furthermore, the\n                    <jats:italic>N<\/jats:italic>\n                    \u2010aryl saccharin adducts function as robust, programmable modified Gabriel reagents, smoothly delivering diverse primary and secondary aryl amine hydrochloride salts in up to 99% yield under remarkably mild conditions.\n                  <\/jats:p>","DOI":"10.1002\/anie.3193418","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:56:46Z","timestamp":1790870206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photocatalytic C\u2013H Amination of Arenes with Saccharin"],"prefix":"10.1002","author":[{"given":"Aeri","family":"Jang","sequence":"first","affiliation":[{"name":"College of Pharmacy and Institute of Drug Research and Development Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyesin","family":"Yim","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Institute of Drug Research and Development Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haein","family":"Jeon","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Institute of Drug Research and Development Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-7657","authenticated-orcid":false,"given":"Jee Eun","family":"Hong","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Institute of Drug Research and Development Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1496-9800","authenticated-orcid":false,"given":"Jinwoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Institute for Sciences of the Universe Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-0624","authenticated-orcid":false,"given":"Seokwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Institute of Drug Research and Development Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6844-2241","authenticated-orcid":false,"given":"Yohan","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Institute of Drug Research and Development Chungnam National University  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