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Here, we report\n                    <jats:bold>RPIB\u2010Cys<\/jats:bold>\n                    , a self\u2010assembled triple\u2010locked near\u2010infrared (NIR) type\u2010I PS that remains photoinactive until activated in the mitochondrial microenvironment of triple\u2010negative breast cancer (TNBC). The molecule is intelligently engineered such that its photoactivity is restored only upon cooperative stimulation by elevated viscosity, alkaline pH, and high cysteine (Cys) levels, three hallmarks of cancer mitochondria. Unlocking simultaneously enables NIR fluorescence\/photoacoustic (PA) imaging and efficient type\u2010I reactive oxygen species (ROS) generation. The resulting photoinduced oxidative stress triggers ferroptosis via glutathione depletion and glutathione peroxidase 4 (GPX4) inactivation, while concurrently inducing pyroptosis through gasdermin D (GSDMD) cleavage. This spatially controlled dual immunogenic cell death (ICD) converts cold TNBC into inflamed tumors, representing a multiple\u2011response activatable type\u2011I PS that uniquely integrates multimodal imaging with the concurrent induction of pyroptosis and ferroptosis for precision photoimmunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/anie.3280921","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:45:38Z","timestamp":1784115938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Triple\u2010Microenvironment Decoding Enables Logic\u2010Unlocked Precision Photoimmunotherapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Chuangjun","family":"Liu","sequence":"first","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering Huanghuai University  Zhumadian 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