{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:08:14Z","timestamp":1789031294973,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Difficult peptides, particularly those enriched in\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010branched hydrophobic residues, readily aggregate but often resist crystallization, limiting their use as substrates for topochemical synthesis. Here, we show that a\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010sheet xerogel (XG) derived from a homochiral valine dipeptide provides a highly ordered supramolecular framework that supports an unprecedented two\u2010stage topochemical azide\u2013alkyne cycloaddition. Mild heating (70\u00b0C) induces quantitative, regiospecific monomer\u2010to\u2010dimer conversion with sigmoidal kinetics while preserving the cross\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    architecture. This first topochemical reaction generates an ordered dimer phase that, upon further heating (160\u00b0C), undergoes a second sigmoidal topochemical reaction in which the dimer becomes the operative reactive repeat unit, affording a regiospecific 1,4\u2010triazole\u2010linked pseudopolypeptide. Differential scanning calorimetry (DSC) reveals two discrete exotherms that are consumed sequentially, while time\u2010resolved PXRD shows evolution of the reaction lattice with retention of the characteristic cross\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    reflections, albeit with changes in the longer\u2010range diffraction features. Fourier transform infrared (FT\u2010IR) spectroscopy further supports preservation of the hydrogen\u2010bonded\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010sheet framework throughout both transformations. Together, these observations reveal a mechanism in which the\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010sheet framework persists while the supramolecular structure reorganizes, redefining the reactive periodicity from monomer to dimer.\n                  <\/jats:p>","DOI":"10.1002\/anie.3298028","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:24:50Z","timestamp":1789028690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sequential Topochemical Reactions Through an Evolving Reaction Lattice"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2690-852X","authenticated-orcid":false,"given":"Bichu","family":"Sebastian","sequence":"first","affiliation":[{"name":"School of Chemistry IISER  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishika","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of California at Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Pandian","sequence":"additional","affiliation":[{"name":"School of Chemistry IISER  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1857-9881","authenticated-orcid":false,"given":"Athira","family":"Cheerakkoda","sequence":"additional","affiliation":[{"name":"Department of Chemistry Materials and Chemical Engineering \u201cGiulio Natta\u201d Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Muthalpuredath","sequence":"additional","affiliation":[{"name":"Institut de Chimie de Strasbourg University of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-3655","authenticated-orcid":false,"given":"Kana M.","family":"Sureshan","sequence":"additional","affiliation":[{"name":"School of Chemistry IISER  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00840K"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1016\/j.chempr.2022.07.028","article-title":"Reversible Topochemical Polymerization and Depolymerization of a Crystalline 3D Porous Organic Polymer With C\u2013C Bond Linkages","volume":"8","author":"Sun C.","year":"2022","journal-title":"Chem"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202417905"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050948\u2010z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC07066A"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b11857"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c07453"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"21331","DOI":"10.1021\/jacs.5c06180","article-title":"Topochemical Ring\u2010Opening Polymerization of an Oxathianethione","volume":"147","author":"Calder\u00f3n\u2010D\u00edaz A.","year":"2025","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c00978"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202116650"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202109344"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b07682"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.3c00941"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c11426"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202500756"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27031048"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35343A"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202415567"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c05415"},{"key":"e_1_2_8_21_1","first-page":"27988","article-title":"Cascade Photoreaction in Crystals: A Phase Change Caused by a Dewar Benzene Quantum Chain Triggers a Topochemical [2 + 2] Photodimerization","volume":"146","author":"Paul I.","year":"2024","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202304722"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b07538"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","unstructured":"A. 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