{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:51:21Z","timestamp":1791557481846,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201021\u2010CE07\u20100022\u201001 NICECAT"],"award-info":[{"award-number":["ANR\u201021\u2010CE07\u20100022\u201001 NICECAT"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Native functional\u2010group conversion represents a powerful complement to C\u2013H methylation, yet the selective installation of methyl groups directly from free carboxylic acids remains an outstanding challenge. Herein, we report a reaction design that addresses these challenges through the integration of Fe\u2010mediated ligand\u2010to\u2010metal charge transfer (LMCT) photocatalysis and Ni\u2010mediated S\n                    <jats:sub>H<\/jats:sub>\n                    2 radical\u2010sorting. Native carboxylic acids are directly converted into alkyl radicals through catalytic Fe\u2013LMCT activation, whereas selective C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500C(sp\n                    <jats:sup>3<\/jats:sup>\n                    ) bond formation is achieved by Ni\u2010mediated S\n                    <jats:sub>H<\/jats:sub>\n                    2 catalysis. Central to this design is a multifunctional cumyl hydroperoxide reagent that simultaneously promotes Fe\u2013LMCT catalyst turnover, generates methyl radicals through a Fenton\u2010type process, and facilitates in situ iron carboxylate formation, thereby merging both catalytic manifolds within a single cooperative reaction network. This platform enables the direct peripheral methyl editing of a broad range of primary, secondary, and tertiary carboxylic acids, including structurally complex and bioactive molecules. Extension to trideuteromethylation further illustrates the modularity of the catalytic platform. Mechanistic studies support the proposed reaction design and the multifunctional role of the peroxide reagent. This work establishes a blueprint for integrating LMCT radical generation with catalytic radical sorting, opening new opportunities for C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500C(sp\n                    <jats:sup>3<\/jats:sup>\n                    ) bond formation through coupled radical processes.\n                  <\/jats:p>","DOI":"10.1002\/anie.3306470","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:16:56Z","timestamp":1791555416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cooperative Fe\u2013LMCT and Ni\u2013S\n                    <sub>H<\/sub>\n                    2 Catalysis for Native Carboxylic Acid Methyl Editing"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8697-0744","authenticated-orcid":false,"given":"Mohammad","family":"Jaber","sequence":"first","affiliation":[{"name":"Universit\u00e9 Lyon 1 Institut de Chimie et Biochimie Mol\u00e9culaires et Supramol\u00e9culaires (ICBMS, UMR 5246 du CNRS)  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6466-7238","authenticated-orcid":false,"given":"Mika\u00ebl Le","family":"Roch","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1 Institut de Chimie et Biochimie Mol\u00e9culaires et Supramol\u00e9culaires (ICBMS, UMR 5246 du CNRS)  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7817-5255","authenticated-orcid":false,"given":"Ga\u00ebl","family":"Tran","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1 Institut de Chimie et Biochimie Mol\u00e9culaires et Supramol\u00e9culaires (ICBMS, UMR 5246 du CNRS)  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-1411","authenticated-orcid":false,"given":"Abderrahmane","family":"Amgoune","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1 Institut de Chimie et Biochimie Mol\u00e9culaires et Supramol\u00e9culaires (ICBMS, UMR 5246 du CNRS)  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01347"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201303207"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200060g"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00973C"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal12050510"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12025"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol502682q"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c03711"},{"issue":"46","key":"e_1_2_7_10_1","first-page":"42311","article-title":"Development, Application, and Mechanistic Interrogation of a Dual Ni Catalysis Approach to Photoredox\u2010Based C(sp3)\u2013C(sp3) Cross\u2010Coupling","volume":"147","author":"Bucci E.","year":"2025","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adl5890"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c02458"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202300166"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08989"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6123"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19056"},{"issue":"24","key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1021\/ja01026a022","article-title":"Photochemical and Thermal Reduction of Cerium(IV) Carboxylates. 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