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Herein, we report a modular molecular design strategy that converts renewable polyphenols into reusable functional building blocks for recyclable epoxy\u2013amine thermosets. Distinct from conventional degradable epoxy networks, this platform enables systematic structural variation and establishes a clear structure\u2013depolymerization relationship. Kinetic and computational analyses further support a previously unrecognized ether\u2010assisted methanolysis mechanism, in which neighboring ether functionalities and a favorable aliphatic amine environment lower the apparent kinetic barrier and modulate the local methanol environment around the cleavable ester bonds in a configuration\u2010dependent manner. Consequently, the resulting thermosets undergo efficient methanolysis under mild conditions (70\u00b0C), affording reusable molecular components while maintaining tunable thermal and mechanical properties. Furthermore, carbon fiber\u2013reinforced composites based on the optimized formulation can be efficiently depolymerized, yielding intact fibers and reusable building blocks in 88% isolated yield. The recovered polyols can be further upcycled into antibacterial quaternary ammonium materials, demonstrating a value\u2010added reuse pathway. This work identifies a previously unrecognized molecular promotion mechanism for catalyst\u2010free methanolysis and translates this mechanism insight into a structural design principle for recyclable polyphenol\u2010based epoxy\u2013amine thermosets.<\/jats:p>","DOI":"10.1002\/anie.3352626","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:10:15Z","timestamp":1789571415000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reusable Polyphenol Building Blocks Enable Recyclable Epoxy\u2010Amine Thermosets via Methanolysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5843-3411","authenticated-orcid":false,"given":"Yi\u2010Min","family":"Tu","sequence":"first","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6570-245X","authenticated-orcid":false,"given":"Yuhang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3053-0497","authenticated-orcid":false,"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory of Eco\u2010Friendly Polymeric Materials (Sichuan), State Key Laboratory of Advanced Polymer Materials, College of Chemistry Sichuan University  Chengdu P. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhe","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1489-6330","authenticated-orcid":false,"given":"Christoph","family":"Tzschucke","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3001-875X","authenticated-orcid":false,"given":"Andreas J.","family":"Achazi","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"},{"name":"IT and Data Services Zuse Institute Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-162X","authenticated-orcid":false,"given":"Rainer","family":"Haag","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Composites United e.V. \u201cAVK Market Report: The European Composites Market 2024 \u201d accessed September 7 2026 https:\/\/composites\u2010united.com\/en\/avk\u2010market\u2010report\u20102024\/."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jppr.2018.04.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.110994"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/logistics3030018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2025.111720"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00713H"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b19085"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.7b01222"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.167486"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1039\/C9GC02068C","article-title":"Sustainable Access to Biobased Biphenol Epoxy Resins by Electrochemical Dehydrogenative Dimerization of Eugenol","volume":"21","author":"Kruijff G. 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