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However, many ROS\u2010generating therapeutic systems rely on heavy metals or structurally complex inorganic architectures, limiting their biological compatibility and catalytic selectivity. Inspired by nonheme iron\u2010mediated redox catalysis, we report a series of water\u2010soluble biomimetic first\u2010row transition metal complexes supported by a picolylamine\u2010derived nonheme ligand scaffold bearing a pendant hydroxyl group. Systematic variation of the metal center (Mn, Fe, Co, Ni, Cu, and Zn) generated divergent electrochemical behavior and distinct peroxide\u2010activation reactivity, yet only the iron complex, [Fe(N\n                    <jats:sub>2<\/jats:sub>\n                    Py\n                    <jats:sub>3<\/jats:sub>\n                    OH)]\n                    <jats:sup>2+<\/jats:sup>\n                    (\n                    <jats:bold>1\u2010Fe<\/jats:bold>\n                    ), promoted hydroxyl radical formation via Fenton\u2010like hydrogen peroxide activation in water. Spectroscopic, electrochemical, and crystallographic analyses revealed a biomimetic coordination environment that stabilizes a quasi\u2010reversible Fe(II)\/Fe(III) redox couple suited to catalytic peroxide activation. In gastric cancer cells,\n                    <jats:bold>1\u2010Fe<\/jats:bold>\n                    induced intracellular oxidative stress, mitochondrial depolarization, lipid peroxidation, and concomitant apoptosis and ferroptosis, while exhibiting negligible toxicity toward normal fibroblasts. In combination with paclitaxel,\n                    <jats:bold>1\u2010Fe<\/jats:bold>\n                    produced synergistic antiproliferative activity in vitro and suppressed peritoneal tumor dissemination in vivo without overt systemic toxicity. Collectively, these results establish biomimetic iron complexes as molecular platforms for Fenton\u2010like oxidative catalysis in redox\u2010based cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/anie.3481625","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:02:17Z","timestamp":1792036937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metal\u2010Center\u2010Controlled Fenton\u2010Like Reactivity of Biomimetic First\u2010Row Transition Metal Complexes in Aqueous Anticancer Catalysis"],"prefix":"10.1002","author":[{"given":"Hyungbin","family":"Park","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; Nanoscience Ewha Womans University  Seoul Republic of Korea"},{"name":"Graduate Program in Innovative Biomaterials Convergence Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungju","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Sookmyung Women's University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8420-5699","authenticated-orcid":false,"given":"Junho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology\u2010Hematology Kyung Hee University Hospital, Kyung Hee University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3653-1546","authenticated-orcid":false,"given":"Myong\u2010Suk","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine Chonnam National University Medical School and Hwasun Hospital  Hwasun Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiseon","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Sookmyung Women's University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1816-6079","authenticated-orcid":false,"given":"Hyeri","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Nanoscience Ewha Womans University  Seoul Republic of Korea"},{"name":"Graduate Program in Innovative Biomaterials Convergence Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaeun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Sookmyung Women's University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0267-1943","authenticated-orcid":false,"given":"Woo Kyun","family":"Bae","sequence":"additional","affiliation":[{"name":"Division of Hemato\u2010Oncology, Department of Internal Medicine Chonnam National University Medical School and Hwasun Hospital  Hwasun Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Hyun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Sookmyung Women's University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7953-8433","authenticated-orcid":false,"given":"Seungwoo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; 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