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Leveraging the overexpressed reactive oxygen species (ROS) in TAD, we reported a hypochlorous acid (HClO)\u2010activatable molecular probe DT\u2010PZ. It enables two\u2010stage self\u2010amplifying fluorescence imaging (chemical activation and then physical aggregation) and light\u2010independent therapy on a single chemical entity. The probe initially exhibits quenched fluorescence via photoinduced electron transfer (PET). Two pathways can turn on the fluorescence via chemical activation: (1) oxidation by HClO blocks PET and turns on the emission; (2) photo\u2010triggered radicals generation of HClO (via chloride ions or myeloperoxidase) to activate neighboring probes, creating self\u2010amplifying fluorescence. Upon accumulation at the lesion site, the physical aggregation caused by the aggregation\u2010induced emission effect further amplifies the fluorescence signals. This two\u2010stage fluorescence amplification mechanism enables TAD visualization within 2\u00a0min in vivo. For therapy, the phenothiazine scavenges excess ROS during non\u2010illuminated periods, down\u2010regulates the NF\u2010\u03baB\/P65 signal pathway, and up\u2010regulates eNOS and P\u2010Akt expressions, protecting endothelial homeostasis and then improving murine survival from 50% to 90%. Collectively, DT\u2010PZ synergizes self\u2010amplifying fluorescence imaging with light\u2010independent antioxidation\/anti\u2010inflammatory therapy, holding great promise for managing deep\u2010seated cardiovascular diseases.<\/jats:p>","DOI":"10.1002\/anie.3622603","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:42:42Z","timestamp":1788345762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Amplifying AIE Probe for HClO\u2010Activatable Imaging and Antioxidative\/Anti\u2010Inflammatory Therapy of Thoracic Aortic Dissection"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0484-2884","authenticated-orcid":false,"given":"Yanzi","family":"Xu","sequence":"first","affiliation":[{"name":"School of Chemistry Engineering Research Center of Energy Storage Materials and Devices Ministry of Education Xi'an Jiaotong University  Xi'an P. 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