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Herein, we report a boron\u2010mediated, nickel\u2010catalyzed strategy that achieves this transformation, enabling the modular assembly of valuable 1,1\u2010diarylalkanes from both simple alkynyl tetracoordinate borons and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acylglutarimides. The reaction proceeds with high regio\u2010 and chemoselectivity under mild conditions, exhibiting good functional group tolerance across both coupling partners. Mechanistic studies support a unique reaction pathway involving dual 1,2\u2010metallate shifts, with water serving as the terminal proton source. The synthetic utility is demonstrated through one\u2010pot synthesis, late\u2010stage functionalization of drugs, gram\u2010scale reactions, and versatile downstream transformations of the products. This strategy represents a distinct strategy that differs from stepwise alkyne reduction, offering a useful disconnection for complex alkane synthesis starting from alkynyl tetracoordinate borons or terminal alkynes via one\u2011pot borylation.\n                  <\/jats:p>","DOI":"10.1002\/anie.3844159","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T13:32:16Z","timestamp":1779456736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nickel\u2010Catalyzed Boron\u2010Mediated Saturative Trifunctionalization of Alkynes"],"prefix":"10.1002","volume":"65","author":[{"given":"Shanglin","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecule Synthesis and Function Discovery Fujian Province University, College of Chemistry, State Key Laboratory of Green and Efficient Development of Phosphorus Resources Fuzhou University  Fuzhou 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