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Generally, a DMSO content of below 1% is believed to exert no effect on cells, and thus little attention is given to its influence on drug efficacy. During our recent research on a lipid droplet\u2010targeted photosensitizer, PNA\u20109, we notice the drastic influence of low\u2010concentration DMSO (&lt;1%) on its photodynamic therapy (PDT) performance. In\u2010depth investigations reveal the significant role of low\u2010concentration DMSO on PNA\u20109 particle size, which further affects cellular uptake via passive diffusion and results in a drastic PDT effect. We further extend our investigation of low\u2010concentration DMSO effect on other common hydrophobic chemotherapy drugs and photosensitizers. The results uncover the differential influences of low\u2010concentration DMSO: camptothecin (CPT) and TPE\u2010IQ possess similar DMSO effects, whilst the therapy effects\u00a0of paclitaxel (PCT), bortezomib (BTZ), and DTTPB are not obviously influenced. This work aims to bring the effect of low\u2010concentration DMSO to attention and is expected to benefit the development of biomaterials and comprehensive material performance evaluation.<\/jats:p>","DOI":"10.1002\/anie.3876737","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:18:21Z","timestamp":1792037901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts"],"prefix":"10.1002","author":[{"given":"Sisi","family":"Yuan","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, School of Science Harbin Institute of Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, School of Science Harbin Institute of Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0234-6801","authenticated-orcid":false,"given":"Hang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences The Chinese University of Hong Kong  Shatin, New Territories Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-5677","authenticated-orcid":false,"given":"Zikai","family":"He","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, School of Science Harbin Institute of Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5263-9189","authenticated-orcid":false,"given":"Sijie","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Sciences The Chinese University of Hong Kong  Shatin, New Territories Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4953-0750","authenticated-orcid":false,"given":"Engui","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, School of Science Harbin Institute of Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"21","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1039\/D2CS00722C","article-title":"Near\u2010infrared (NIR) Fluorescence\u2010emitting Small Organic Molecules for Cancer Imaging and Therapy","volume":"51","author":"Li H.","year":"2022","journal-title":"Chemical Society Reviews"},{"issue":"22","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1039\/D3QM00679D","article-title":"Recent Advances in Aggregation\u2010induced Emission (AIE)\u2010based Chemosensors for the Detection of Organic Small Molecules","volume":"7","author":"Chua M. 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