{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:52:57Z","timestamp":1784739177459,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"30","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,7,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Traditional dynamic therapies, including photodynamic, sonodynamic and chemodynamic therapies, are limited by shallow penetration and lack of sustained effects. X\u2010ray induced dynamic therapy overcomes penetration barriers, yet current inorganic materials raise biosafety concerns, while organic counterparts often show low reactive oxygen species (ROS) yield. To address these limitations, we propose X\u2010ray induced long\u2010acting dynamic therapy, a minimally invasive strategy for deep\u2010tissue tumor treatment. We propose X\u2010ray induced persistent ROS generation and luminescence mechanisms in fused\u2010triple\u2010anthracene nanoparticles (FTA NPs), which generate electrons and FTA\n                    <jats:sup>\u2022+<\/jats:sup>\n                    under X\u2010ray irradiation to producing singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) and hydroxyl radicals (OH), while endoperoxides (EPOs) sustain ROS and afterglow luminescence for over 15\u00a0min, with relatively stronger afterglow than conventional organic afterglow materials, such as MEHPPV NPs. In addition, FTA NPs achieve 6\u00a0cm tissue penetration under X\u2010ray, overcoming light limitations and boosting therapeutic efficacy. Furthermore, we introduce fractionated irradiation, splitting high doses into multiple low\u2010dose sessions, which enhances ROS generation, reduces radiation risk and more effectively treats subcutaneous and orthotopic pancreatic tumors than continuous irradiation. Strong afterglow luminescence allows real\u2010time imaging and treatment monitoring, while metal\u2010free FTA NPs ensure high biocompatibility and safety. Thus, long\u2010acting dynamic therapy offers a safe and efficient strategy for deep\u2010seated tumors.\n                  <\/jats:p>","DOI":"10.1002\/anie.3922737","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T11:48:16Z","timestamp":1779536896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010Acting Dynamic Therapy Using X\u2010Ray Activated Organic Nanoparticles for Afterglow Imaging Guided Deep Tumor Treatment"],"prefix":"10.1002","volume":"65","author":[{"given":"Baoli","family":"Yin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University  Changsha China"},{"name":"College of Public Health Zhengzhou University  Zhengzhou 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Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehong","family":"Hu","sequence":"additional","affiliation":[{"name":"Research Center for Advanced Detection Materials and Medical Imaging Devices Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  Shenzhen China"},{"name":"State Key Laboratory of Biomedical Imaging Science and System Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyan","family":"Huan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heemin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Korea University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6570-3772","authenticated-orcid":false,"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-029X","authenticated-orcid":false,"given":"Zonghai","family":"Sheng","sequence":"additional","affiliation":[{"name":"Research Center for Advanced Detection Materials and Medical Imaging Devices Institute of Biomedical and Health Engineering Shenzhen Institute of 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