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Building on cyclodextrin (CD) host\u2013guest self\u2010assembly, we designed a monomer bearing an adamantyl unit to promote inclusion\u2010mediated polymerization, a bridge across the CD cavity to prevent self\u2010inclusion, and a sialic acid (SA) ligand to engage spike glycan\u2010recognition sites. A series of SA\u2010functionalized self\u2010assembling CDs was synthesized, together with nonassembling and nonbinding controls. In cellular infection assays, the SA\u2010functionalized self\u2010assembling CD inhibited SARS\u2010CoV\u20102\u2010induced cytopathic effect (CPE) without detectable cytotoxicity, whereas controls were inactive, indicating that both self\u2010assembly and ligand recognition are required for antiviral activity. NMR and cryo\u2010electron microscopy studies of the active SA\u2010functionalized self\u2010assembling CD show that the viral surface mediates supramolecular polymer growth by nucleating cooperative supramolecular polymerization through ligand\u2013receptor recognition. Inhibition was maintained across multiple SARS\u2010CoV\u20102 variants, consistent with adaptive assembly. Coassembly with an unfunctionalized self\u2010assembling CD preserved strong inhibition at low ligand fractions, supporting heteropolymer formation with optimized ligand spacing. These findings establish virus\u2010mediated supramolecular polymerization of functional CDs as a modular antiviral platform.<\/jats:p>","DOI":"10.1002\/anie.3935543","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:30:07Z","timestamp":1784118607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Virus\u2010Mediated Self\u2010Assembly of Functional Cyclodextrins for Antiviral Inhibition"],"prefix":"10.1002","volume":"65","author":[{"given":"Pedro J.","family":"Hernando","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS Institut Parisien de Chimie Mol\u00e9culaire, IPCM Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laora","family":"Boulo","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS Institut Parisien de Chimie Mol\u00e9culaire, IPCM Paris 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