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This limitation is primarily attributed to the robust endocyclic C\u2014O bonds, its aromaticity, and the lack of strategies to activate inert oxygen atoms. In this study, we report a lithium\u2010mediated strategy that enables the divergent transmutation of furan oxygen atoms. By employing a mechanochemical ball\u2010milling protocol, we achieve this transformation under mild and operationally simple conditions, significantly enhancing the efficiency compared to conventional solution\u2010phase methods. This approach enables the precise replacement of oxygen with diverse elements\u2014including silicon, carbon, selenium, phosphorus, germanium, and titanium\u2014via deoxygenatively dilithiated intermediates that react in situ with various electrophiles, thereby providing direct access to a library of valuable heterocycles. This work highlights a versatile platform for molecular diversification with endocyclic transmutation, demonstrating that mechanochemistry can serve as an operationally efficient and time\u2010saving strategy for complex heterocycle synthesis.<\/jats:p>","DOI":"10.1002\/anie.4084841","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:10:15Z","timestamp":1789834215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Divergent Single\u2010Oxygen Transmutation of Furans"],"prefix":"10.1002","author":[{"given":"Yi","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry &amp; Materials Science Northwest University  Xi'an P. R. 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