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However, their application is constrained by the scarcity of stable organic piezoelectric systems. Here, we develop a one\u2010step electrospinning strategy for self\u2010assembling organic heterostructured piezoelectric nanofibers to combat tumor metastasis. In this system, directional hydrogen bonding between the \u2500NH\n                    <jats:sub>2<\/jats:sub>\n                    groups of diphenylalanine (FF) and the C\u2550O groups of poly(L\u2010lactic acid) (PLLA), alongside van der Waals interactions, critically promotes oriented PLLA chain crystallization and stabilizes the piezoelectric \u03b2\u2010phase. The resulting PLLA@FF composite exhibits enhanced piezoelectric performance and excellent stability. Under ultrasound irradiation, injectable PLLA@FF generates a potent sonopiezoelectric effect, triggering a reactive oxygen species storm that induces mitochondrial dysfunction, robust apoptosis, and the release of damage\u2010associated molecular patterns, thereby initiating an immunogenic cell death cascade. In vivo studies demonstrate that PLLA@FF\u2010mediated sonopiezoelectric therapy not only suppresses primary and distant tumor growth but also inhibits lung metastasis by remodeling the immunosuppressive tumor microenvironment. RNA sequencing further corroborates these findings, revealing activation of oxidative stress, apoptosis, and immune\u2010related pathways. Collectively, this work overcomes the stability limitations of piezoelectric polymers and establishes a versatile, biodegradable fibrous platform for advanced piezocatalytic immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/anie.4212622","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:11:41Z","timestamp":1790064701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydrogen\u2010Bonding\u2010Stabilized Organic Piezoelectric Nanofibers for Immunogenic Sonopiezodynamic Therapy of Metastatic Tumors"],"prefix":"10.1002","author":[{"given":"Run","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Life Sciences Shanghai University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziting","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Life Sciences Shanghai University  Shanghai P. R. 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