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We herein report a novel near\u2010infrared (NIR) photocatalyst, constructed by conjugating a Pt(II) porphyrin with a cyanine dye. Upon 808\u00a0nm irradiation, it operates via dual energy\/electron\u2010transfer pathways to simultaneously generate reactive oxygen species (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , O\n                    <jats:sub>2<\/jats:sub>\n                    \u00b7\n                    <jats:sup>\u2212<\/jats:sup>\n                    , \u00b7OH) and oxidize the metabolic cofactor NADH. This dual action disrupts redox balance and induces immunogenic cell death. Delivered as biocompatible nanoparticles, the system enables precise tumor delineation by fluorescence (FL)\/photoacoustic (PA) imaging, and proceeds by activating tumor\u2010specific cytotoxic T cells, thus impeding both primary and distant tumor progression to achieve high therapeutic efficiency. 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