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Here, we designed a strain\u2010engineered nanozymes (PWO) based on platinum (Pt) nanodots epitaxially grown on tungsten oxide (WO\n                    <jats:sub>x<\/jats:sub>\n                    ) nanoribbons, which introduced inhomogeneous lattice strain. The phonon spectrums reveal the different influences on acoustic and optical branches caused by inhomogeneous strain. Enhanced acoustic phonon scattering promotes elastic electron\u2013phonon interactions, enabling hot electrons to retain energy as confined lattice heat rather than dissipating as bulk photothermal output. Consequently, the photothermal conversion efficiency of WO\n                    <jats:sub>x<\/jats:sub>\n                    decreased from 37.19% (unstrained) to 20.80% (strained), confirming the formation of confined lattice heat. Under the synergistic effect of confined lattice heat and contact potential difference, the activation energy of the enzymatic catalytic reaction was reduced by 51.30% due to hot electrons. Moreover, PWO caused damage to mitochondria and the cytoskeleton, leading to the eventual induction of apoptosis in tumor cells. These results elucidate the physical manifestation of electron\u2010phonon and phonon\u2010phonon scattering under inhomogeneous strain and provide a general strategy for improving nanozyme catalysis via hot\u2010electron regulation in enzymatic therapy.\n                  <\/jats:p>","DOI":"10.1002\/anie.4271452","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:13:05Z","timestamp":1776683585000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhomogeneous Strain\u2010Modulated Phonon Scattering Sustains Hot Electrons for Enhanced Enzymatic Therapy"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7638-1169","authenticated-orcid":false,"given":"Sida","family":"Cao","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology College of Materials Science and Chemical Engineering Ministry of Education Harbin Engineering University  Harbin P. 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