{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:54:02Z","timestamp":1791431642015,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM147135"],"award-info":[{"award-number":["R01GM147135"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE\u20102203284"],"award-info":[{"award-number":["CHE\u20102203284"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008510","name":"University of Maryland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Selective deuterium incorporation into aromatic molecules is important in mechanistic studies, medicinal chemistry, and isotope\u2010enabled molecular design, yet methods that combine inexpensive deuterium sources, mild reducing conditions, broad functional\u2010group tolerance, and high deuterium incorporation remain scarce. Here we report a disilane\u2010enabled palladium\u2010catalyzed dehalogenative deuteration of aryl and benzylic halides using D\n                    <jats:sub>2<\/jats:sub>\n                    O as the deuterium source. The reaction proceeds under mild conditions across a broad substrate range, furnishing more than 60 deuterated products in generally high yields and with typically &gt;95% deuterium incorporation. Carboxylic acids, reduction\u2010sensitive functional groups, and \u03c0\u2010unsaturated motifs are all tolerated, and the protocol is readily scalable. Mechanistic studies are consistent with a disilane\u2010assisted pathway in which fluoride\u2010mediated activation of the disilane promotes the conversion of arylpalladium intermediates to deuterated products using D\n                    <jats:sub>2<\/jats:sub>\n                    O as the deuterium source. This operationally simple method provides direct access to selectively deuterated arenes from readily available halides and establishes disilanes as pathway\u2010enabling reagents for palladium\u2010catalyzed dehalogenative functionalization.\n                  <\/jats:p>","DOI":"10.1002\/anie.4335022","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:26:46Z","timestamp":1791430006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Mild Disilane\u2010Enabled Halide\u2010to\u2010Deuterium Manifold With D\n                    <sub>2<\/sub>\n                    O for Aryl and Benzylic Halides"],"prefix":"10.1002","author":[{"given":"Wenliang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3857-3143","authenticated-orcid":false,"given":"Ryan","family":"Parlett","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Hornstein","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5471-1192","authenticated-orcid":false,"given":"Landon","family":"Conklin","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3189-1315","authenticated-orcid":false,"given":"Xiaodong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/anie.201704146","article-title":"Deuterium\u2010 and Tritium\u2010Labelled Compounds: Applications in the Life Sciences","volume":"57","author":"Atzrodt J.","year":"2018","journal-title":"Angewandte Chemie International Edition"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41573-023-00703-8","article-title":"Deuterium in Drug Discovery: Progress, Opportunities and Challenges","volume":"22","author":"Di Martino R. 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Tertiary Amide and O\u2010Carbamate Directors in Synthetic Strategies for Polysubstituted Aromatics","volume":"90","author":"Snieckus V.","year":"1990","journal-title":"Chemical Reviews"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1021\/jo01267a088","article-title":"Preparation of 1\u2010Deuteriobenzaldehydes by Lithium Aluminum Deuteride Reduction of N\u2010tert\u2010Butylbenzamides","volume":"33","author":"Axenrod T.","year":"1968","journal-title":"Journal of Organic Chemistry"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1016\/S0040-4039(01)87313-5","article-title":"Site\u2010Specific Method for Deuteration: Reduction of Aryl Halides With Sodium Borodeuteride and Palladium Chloride","volume":"14","author":"Bosin T. 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Y.","year":"2017","journal-title":"Science"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/anie.201811522","article-title":"Deoxygenative Deuteration of Carboxylic Acids With D2O","volume":"58","author":"Zhang M.","year":"2019","journal-title":"Angewandte Chemie International Edition"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41586-024-07989-7","article-title":"Electrocatalytic Reductive Deuteration of Arenes and Heteroarenes","volume":"634","author":"Bu F.","year":"2024","journal-title":"Nature"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/s41929-025-01379-6","article-title":"Boron Clusters as Efficient Shuttles for Electrocatalytic Deuterium Labeling via Radical H\/D Exchange","volume":"8","author":"He M.","year":"2025","journal-title":"Nature Catalysis"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1039\/D4QO01030B","article-title":"Photocatalyzed Dehalogenative Deuteration with Silacarboxylic Acids as Halogen\u2010Atom Transfer Agents","volume":"11","author":"Hu J.\u2010W.","year":"2024","journal-title":"Organic Chemistry Frontiers"},{"key":"e_1_2_8_19_1","volume-title":"Organotransition Metal Chemistry: From Bonding to Catalysis","author":"Hartwig J. 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