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This relationship enforces a persistent trade\u2010off: glasses with low glass transition temperatures, essential for gentle processing, are inherently unstable and prone to rapid crystallization. Here, we report a noncovalent glass system that, defies this paradigm, achieving an exceptional crystallization barrier exceeding 653.2\u00a0kJ mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    , while maintaining a moderate glass transition temperature below 332.3\u00a0K. This anomalous decoupling originates from a \u201cnoncovalent cluster packing\u201d architecture where internally rigid, hydrogen\u2010bonded nanoclusters are loosely interconnected by weak interactions. This distinct topology effectively isolates local structural rigidity from global relaxation, creating a landscape that, suppresses nucleation pathways. We demonstrate the practical utility of this principle through the robust room\u2010temperature preservation and delivery of labile biomolecules. By challenging conventional theoretical constraints, this work establishes a general design strategy for creating ultrastable yet functionally versatile amorphous materials.\n                  <\/jats:p>","DOI":"10.1002\/anie.4411241","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:57:20Z","timestamp":1773003440000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Noncovalent Cluster Packing Enables Ultrastable Glasses for Preservation and Delivery of Labile Biomolecules"],"prefix":"10.1002","volume":"65","author":[{"given":"Wei","family":"Fan","sequence":"first","affiliation":[{"name":"Institute of Process Engineering Chinese Academy of Sciences State Key Laboratory of Biopharmaceutical Preparation and Delivery  Beijing 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