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Supramolecular assembly enables precise control over molecular packing, local microenvironments, and intermolecular electronic coupling without altering the chromophore scaffold, thereby offering a versatile approach to modulate the photophysical and photochemical behavior of PSs through noncovalent interactions. In this Minireview, we summarize recent advances in supramolecular strategies for modulating the excited\u2010state properties of PSs in PDT. We focus on two central aspects: promoting intersystem crossing to enhance triplet\u2010state formation, and modulating excited\u2010state deactivation pathways to regulate ROS generation and bias Type\u2010I or Type\u2010II photodynamic processes. Representative examples are discussed to illustrate how supramolecular assembly can reduce singlet\u2010triplet energy gaps, introduce charge\u2010transfer (CT) mediators, suppress nonproductive decay, and facilitate electron or hydrogen atom transfer (HAT) reactions. 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