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Achieving their valorization and late\u2010stage functionalization is of great scientific value and broad application prospects. Herein, we report a novel C\u2500C bond formation of phenols in which a visible\u2010light\u2010driven photoredox catalytic system mediates 1,4\u2010aryl migration initiated by trifluoromethyl or sulfonyl radicals, enabling efficient conversion of phenolic derivatives into\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010arylpropionic acids via C\u2500O bond cleavage. The transformation exhibits broad functional\u2010group tolerance, enables modular installation of fluoroalkyl and sulfonyl groups, accommodates diverse migrating aryl groups, and has been demonstrated in the late\u2010stage functionalization of 11 complex phenolic natural products and drug derivatives. Notably, this study represents the application of a reductive radical\u2013polar\u2010crossover process to a 1,4\u2010aryl migration involving aryl C\u2500O bond heterolytic cleavage, enabling efficient C\u2500O bond activation and effective suppression of undesired CO\n                    <jats:sub>2<\/jats:sub>\n                    extrusion. Density functional theory (DFT) calculations support the proposed mechanism and elucidate the origin of the suppression of the decarboxylation pathway.\n                  <\/jats:p>","DOI":"10.1002\/anie.4827662","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:43:17Z","timestamp":1790826197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photoredox Conversion of Phenol Derivatives Into\n                    <i>\u03b2<\/i>\n                    \u2010Arylpropionic Acids via Radical 1,4\u2010Aryl Migration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0487-0764","authenticated-orcid":false,"given":"Kun","family":"Long","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Natural Product Chemistry, and College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou P.R. 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