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Here, we established a rapid and experimentally accessible workflow for temporally controlled HP measurements in living cells. Using SABRE\u2010SHEATH at 0.4\u00a0\u00b5T, we achieved 7.7% \u00b1 0.2%\n                    <jats:sup>13<\/jats:sup>\n                    C polarization of 50\u00a0mM [1\u2010\n                    <jats:sup>13<\/jats:sup>\n                    C]pyruvate within 60 s. Simple 1:50 dilution with phosphate\u2010buffered D\n                    <jats:sub>2<\/jats:sub>\n                    O yielded cell\u2010compatible solutions that retained 5.3% \u00b1 0.4% polarization of 1.3\u00a0mM pyruvate without multi\u2010step purification. Combined with a simplified agarose bead immobilization approach, this enabled four injections of HP pyruvate into the same HeLa cell population within 7\u00a0min. Under rapid (\u22482\u00a0min) reinjection intervals, the pyruvate\u2010to\u2010lactate conversion progressively declined, whereas stable metabolic conversion was maintained at 20\u00a0min intervals with intermittent cell medium perfusion. These findings demonstrate that rapid repeated substrate delivery can transiently exhaust cellular metabolic conversion capacity. This experimentally accessible operating mode enables the study of short\u2010term metabolic dynamics that remain obscured in conventional single\u2010shot HP\u2010NMR or long timescale thermally polarized NMR measurements.\n                  <\/jats:p>","DOI":"10.1002\/anie.4855536","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:33:23Z","timestamp":1783679603000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Minute\u2010Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen\u2010Based Hyperpolarization"],"prefix":"10.1002","volume":"65","author":[{"given":"Philipp R.","family":"Gro\u00df","sequence":"first","affiliation":[{"name":"Division of Medical Physics Department of Radiology Medical Center and Faculty of Medicine  Freiburg Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Freiburg a Partnership Between DKFZ and University 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