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Photodynamic immunotherapy (PDIT) offers a promising alternative, yet its efficacy depends on photosensitizers that can simultaneously generate reactive oxygen species (ROS) and activate antitumor immunity. Herein, three thiophene (T) dyes based on triphenylamine (D) and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010ethyl\u2010benzoselenazolium iodide (Se) (DTSe)\u2010based photosensitizers were molecularly engineered by modulating the \u03c0\u2010conjugated structure. Incorporation of a carbazole unit affords DZTSe with suppressed fluorescence, enlarged Huang\u2013Rhys factor, reduced singlet\u2010triplet energy gap, and prolonged triplet\u2010state lifetime, resulting in enhanced ROS generation. Notably, DZTSe exhibits multi\u2010organelle localization in the endoplasmic reticulum and mitochondria, concurrently inducing pyroptosis and activating the cGAS\u2010STING pathway. This dual stress\u2010immune activation reprograms the tumor microenvironment and enables effective eradication of primary tumors and suppression of distant lesions in vivo, providing a molecular blueprint for immune\u2010activating photosensitizers.\n                  <\/jats:p>","DOI":"10.1002\/anie.4883627","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:48:48Z","timestamp":1784803728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Engineering Boosts Photon\u2010Activated Immunotherapy for Prostate Cancer Through Concurrent Pyroptosis and cGAS\u2010STING Pathway Activation"],"prefix":"10.1002","volume":"65","author":[{"given":"Cheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, MOE Key Laboratory of Bio\u2010Intelligent Manufacturing, School of 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