{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:43:24Z","timestamp":1775540604099,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201024\u2010INBS\u20100005 FBI BIOGEN"],"award-info":[{"award-number":["ANR\u201024\u2010INBS\u20100005 FBI BIOGEN"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,4,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The 2012 study by Zhu et\u00a0al. (DOI: 10.1002\/anie.201109089) reporting a hybrid nanosystem composed of carbon and CdSe\/ZnS quantum dots functionalized with tris(pyridin\u20102\u2010ylmethyl)ethane\u20101,2\u2010diamine (CdSe@C\u2010TPEA) as ratiometric fluorescent sensors for intracellular copper imaging remains highly influential, with 499 citations to date (Web of Science, December 4, 2025). As part of the NanoBubbles replication project, we attempted to reproduce key experimental findings following detailed pre\u2010registered protocols. Despite strict adherence to the reported synthesis procedures, we failed to replicate the central claim of Cu\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010induced fluorescence quenching. Furthermore, our analysis reveals significant data anomalies in the original publication, including spectral overlaps with identical noise patterns inconsistent with independent measurements. These findings raise critical concerns regarding data integrity and reproducibility and cast significant doubt on the reliability of Zhu et\u00a0al.\u2019s reported results.\n                  <\/jats:p>","DOI":"10.1002\/anie.4904466","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:22:32Z","timestamp":1772997752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correspondence on \u201cCarbon\u2010Dot\u2010Based Dual\u2010Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for in Vivo Imaging of Cellular Copper Ions\u201d"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-1101","authenticated-orcid":false,"given":"Mustafa","family":"Gharib","sequence":"first","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord and Universit\u00e9 Paris Cit\u00e9 INSERM LVTS  Paris F\u201075018 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8831-9854","authenticated-orcid":false,"given":"Maha","family":"Said","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord and Universit\u00e9 Paris Cit\u00e9 INSERM LVTS  Paris F\u201075018 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5728-0531","authenticated-orcid":false,"given":"Rapha\u00ebl","family":"L\u00e9vy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Sorbonne Paris Nord and Universit\u00e9 Paris Cit\u00e9 INSERM LVTS  Paris F\u201075018 France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs15309b"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023997\u2010x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201109089"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.7993122"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.15432460"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.31219\/osf.io\/kf9qe"},{"key":"e_1_2_8_8_1","article-title":"Replicating, Revising and Reforming: Unpicking the Apparent Nanoparticle Endosomal Escape Paradox","author":"Linnane E.","year":"2024","journal-title":"Peer Community in Registered Reports"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.31219\/osf.io\/2x3hv_v3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.24072\/pci.rr.101070"},{"key":"e_1_2_8_11_1","article-title":"PubPeer Comment on Carbon\u2010Dot\u2010Based Dual\u2010Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for in\u2005Vivo Imaging of Cellular Copper Ions","author":"Gharib M.","year":"2025","journal-title":"PubPeer"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.4904466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.4904466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.4904466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:43:33Z","timestamp":1775537013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.4904466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":10,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,4,6]]}},"alternative-id":["10.1002\/anie.4904466"],"URL":"https:\/\/doi.org\/10.1002\/anie.4904466","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e4904466"}}