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Its deuterated analogue, the (deuterio)difluoromethyl group (\u2013CF\n                    <jats:sub>2<\/jats:sub>\n                    D), offers further potential for enhancing metabolic stability and enabling distinct intermolecular interactions. Molecules bearing vicinal difluoromethyl or (deuterio)difluoromethyl groups can serve as potential bioisosteres of pharmacologically important vicinal diols and amino alcohols. Consequently, the direct and simultaneous installation of two difluoromethyl and (deuterio)difluoromethyl groups across alkenes represents an important synthetic target. To address current limitations, we herein introduced 2\u2010CF\n                    <jats:sub>2<\/jats:sub>\n                    H(D)\u2010imidazolium salts as a robust, user\u2010friendly reagent platform for both bis(difluoromethylation) and bis(deuterio)difluoromethylation of a broad range of alkenes, including aryl\u2010substituted and less reactive alkyl derivatives. The synthetic utility of this method is demonstrated through late\u2010stage functionalization and gram\u2010scale synthesis of complex molecules. Preliminary mechanistic studies revealed their distinct behavior in copper and photoredox catalysis. As such, this work establishes these reagents as a versatile platform for the simultaneous formation of C\u2500CF\n                    <jats:sub>2<\/jats:sub>\n                    H and C\u2500CF\n                    <jats:sub>2<\/jats:sub>\n                    D bonds, representing a significant advance in the synthesis of valuable fluorinated and deuterated compounds.\n                  <\/jats:p>","DOI":"10.1002\/anie.4947785","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:53:56Z","timestamp":1785941636000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["2\u2010CF\n                    <sub>2<\/sub>\n                    H(D)\u2010Imidazolium Salts: A Reagent Platform for Bis(Deuterio)Difluoromethylation of Alkenes Under Copper\/Photoredox Dual Catalysis"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1315-2851","authenticated-orcid":false,"given":"Yazhou","family":"Zhang","sequence":"first","affiliation":[{"name":"Center For Supramolecular Chemistry &amp; 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