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Transforming furans into nitrogen\u2010containing heterocycles is an efficient strategy for expanding molecular diversity and enhancing chemical and biological properties.\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heterocycles such as pyrimidines, pyrroles, and pyridazines often exhibit improved stability, enhanced hydrogen\u2010bonding capacity, and favorable pharmacokinetic profiles. Herein, we report a scaffold\u2010hopping strategy that converts furans into\n                    <jats:italic>N<\/jats:italic>\n                    \u2010heterocycles using tunable sulfenylnitrenes. Mechanistic investigations, including isotopic labeling experiments supported by DFT calculations, reveal a unique reaction pathway.\n                  <\/jats:p>","DOI":"10.1002\/anie.4976267","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:22:48Z","timestamp":1790310168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tunable Sulfenylnitrenes Enable Scaffold Hopping of Furans Into\n                    <i>N<\/i>\n                    \u2010Heterocycles"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2069-7011","authenticated-orcid":false,"given":"Prakash","family":"Kafle","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8242-5939","authenticated-orcid":false,"given":"Prabhat","family":"Kharel","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishav","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6835-6429","authenticated-orcid":false,"given":"Shuhei","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deacon","family":"Herndon","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rylan C.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9986-0097","authenticated-orcid":false,"given":"Daillin L.","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Novruz G.","family":"Akhmedov","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0707-0621","authenticated-orcid":false,"given":"Indrajeet","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Furan Derivatives\u2010Recent Advances and Applications","author":"Alabi K. 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