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Constructing an O\n                    <jats:sub>2<\/jats:sub>\n                    \u2011enriched microenvironment alleviates transport issues, while tuning *OOH adsorption prevents excessive O\u2500O bond cleavage; their synergy is expected to boost ORR performance. Guided by theory, we developed a Sn single\u2011atom\u2010anchored hollow mesoporous carbon nanoreactor (Sn\n                    <jats:sub>1<\/jats:sub>\n                    \/HMCS). The hollow mesoporous carbon nanoreactor facilitates an oxygen\u2011enriched microenvironment at the catalytic interface via spontaneous O\n                    <jats:sub>2<\/jats:sub>\n                    adsorption and diffusion, while the N\/O\u2011coordinated Sn sites enable optimal *OOH adsorption regulation, delivering \u223c100% H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    selectivity. The adaptive matching between the spontaneous oxygen supply kinetics and the electrocatalytic reaction allows the system to maintain both optimal thermodynamic potential and high selectivity at industrially relevant high\u2011current conditions. Assembling Sn\n                    <jats:sub>1<\/jats:sub>\n                    \/HMCS in a solid\u2011electrolyte cell delivered an industrial\u2011scale system for high\u2011purity H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    with low energy consumption and excellent stability. At 500\u00a0mA cm\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>2<\/jats:sup>\n                    , it produced \u223c4.51 wt% H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    at a rate of 31.8\u00a0mol g\n                    <jats:sub>catalyst<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    h\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    , with stable operation over 300\u00a0h. This work provides a practical way to prepare catalysts meeting industrial\u2011scale current density requirements and facilitates the development of economically feasible H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    electrosynthesis schemes.\n                  <\/jats:p>","DOI":"10.1002\/anie.5058302","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:46:57Z","timestamp":1790315217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxygen Enrichment on Carbon Nanoreactors and *OOH Modulation on Sn\n                    <sub>1<\/sub>\n                    Sites Cooperatively Promote Industrial\u2010Scale H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    Electrosynthesis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9308-326X","authenticated-orcid":false,"given":"Chao","family":"Miao","sequence":"first","affiliation":[{"name":"School of Chemical Science and Engineering Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji Hospital Tongji University Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Engineering Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji Hospital Tongji University Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixu","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Engineering Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji Hospital Tongji University Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Gong","sequence":"additional","affiliation":[{"name":"Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute, Chinese Academy of Sciences  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-9796","authenticated-orcid":false,"given":"lina","family":"Li","sequence":"additional","affiliation":[{"name":"Suzhou Foreign Language School  Suzhou Jiangsu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-1193","authenticated-orcid":false,"given":"Guohua","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Engineering Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Tongji Hospital Tongji University Shanghai P. R. 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