{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:05:05Z","timestamp":1790348705749,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000287","name":"Royal Academy of Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Photosynthesis compartmentalizes reactions across the thylakoid membrane in vivo to upcycle CO\n                    <jats:sub>2<\/jats:sub>\n                    into complex chemicals that are fundamental to life. Herein, we demonstrate a step toward achieving a synthetic equivalent to the chloroplast with a compartmentalized cascade reaction in vitro that enables light driven CO\n                    <jats:sub>2<\/jats:sub>\n                    utilization for organic synthesis in one\u2010pot. This bioinspired compartmentalization enables the photocatalytic reduction of aqueous CO\n                    <jats:sub>2<\/jats:sub>\n                    by water\u2010soluble catalysts and dyes to produce CO, which then moves into the more buoyant organic layer and is consumed in aminocarbonylation or carbonylative variants of Sonogashira and Suzuki couplings, including the synthesis of the pharmaceutical itopride. The reaction compartmentalization significantly increases the biomimicry of CO\n                    <jats:sub>2<\/jats:sub>\n                    utilization by enabling the light\u2010driven generation and utilization of CO from CO\n                    <jats:sub>2<\/jats:sub>\n                    for chemical synthesis in the same pot compared to previous two\u2010pot approaches. The fundamental platform and design criteria described herein can enable future reactions to utilize building blocks as abundant as CO\n                    <jats:sub>2<\/jats:sub>\n                    to generate complex molecules through bioinspired pathways.\n                  <\/jats:p>","DOI":"10.1002\/anie.5220236","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:47:31Z","timestamp":1790347651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One\u2010Pot Biphasic Photocatalytic CO\n                    <sub>2<\/sub>\n                    \u2010to\u2010Carbonylation Cascades"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7159-7022","authenticated-orcid":false,"given":"Sampurna","family":"Mitra","sequence":"first","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2415-9239","authenticated-orcid":false,"given":"David M.","family":"Vahey","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3285-4356","authenticated-orcid":false,"given":"Shannon A.","family":"Bonke","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-1616","authenticated-orcid":false,"given":"Erwin","family":"Reisner","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Climate Watch \u201cClimate Watch Data\u201d https:\/\/climatewatchdata.org\/ghg\u2010emissions (accessed 15 August 2025)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/B802262N"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.49.2.266"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1525"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/186136a0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004\u2010023\u201001069\u2010z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224581"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b04975"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b04023"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c01725"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c01305"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010019\u20100501\u20106"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b09212"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00705"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav3506"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41560\u2010023\u201001262\u20103"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c14099"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010023\u201000962\u2010z"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5SC00764J"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13249"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010019\u20100383\u20107"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00937a004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104039(00)91094\u20103"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr050992x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104039(01)95429\u20102"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1981.879"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00039a007"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2903"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160\u2010023\u201000411\u20106"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201004693\u20107"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nenergy.2017.131"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00392"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00496"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010023\u201000243\u2010w"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202500715"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201000559\u20108"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010018\u20100051\u20103"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201030676\u2010y"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040136\u2010w"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC06660J"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160\u2010023\u201000458\u20105"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c07343"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c05832"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adr9672"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2459"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202403674"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199301313"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc43031f"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic502707t"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr60281a001"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201205915"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201300459"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo801279r"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joule.2023.05.022"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2330025"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/jz4013678"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b04421"},{"key":"e_1_2_8_59_1","volume-title":"Atkins\u2019 Physical Chemistry","author":"Atkins P.","year":"2006"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200502017"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00076a079"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol5003362"},{"key":"e_1_2_8_63_1","unstructured":"Y.Itoh H.Kato E.Koshinaka N.Ogawa H.Nishino andJ.Sakaguchi Amide Compounds Process for Preparing the Same and Composition for Activating Gastric Motor Function Containing the Same 1991 US4983633A."},{"key":"e_1_2_8_64_1","unstructured":"Verified Market Reports \u201cItopride Market Size Market Overview & Forecast \u201d can be found under https:\/\/www.verifiedmarketreports.com\/product\/itopride\u2010market (accessed 25 October 2025)."},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja200818w"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC01276D"},{"key":"e_1_2_8_67_1","first-page":"145","volume-title":"Development of Advanced High Throughput Experimentation Platforms for Photocatalytic Reactions in The Power of High\u2010Throughput Experimentation","author":"Casadevall C.","year":"2022"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NJ03807B"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b00245"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.4c00048"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol101228k"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA28855C"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b01466"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.5220236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.5220236","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.5220236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:47:34Z","timestamp":1790347654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.5220236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":72,"alternative-id":["10.1002\/anie.5220236"],"URL":"https:\/\/doi.org\/10.1002\/anie.5220236","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"2026-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5220236"}}