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To address these challenges, we have developed an innovative thermally activated delayed fluorescence (TADF)\u2010based photosensitizer, termed TA2O. Leveraging its advantageous TADF properties, including a small singlet\u2010triplet energy gap and prolonged triplet state lifetime, TA2O efficiently generates reactive oxygen species (ROS) upon light irradiation. This process triggers caspase\u20111\/GSDME\u2011dependent pyroptosis, leading to the release of tumor\u2010associated antigens and damage\u2010associated molecular patterns that stimulate adaptive immunity. Concurrently, the accumulation of cytosolic DNA activates the cGAS\u2010STING pathway, thereby bolstering innate immune responses. Both in vitro and in vivo studies demonstrate that TA2O effectively eradicates tumor cells, promotes dendritic cell (DC) maturation, facilitates cytotoxic T lymphocyte infiltration, and induces a marked M2\u2010to\u2010M1 macrophage polarization, effectively promoting immune infiltration and inflammatory remodeling of the tumor microenvironment. Moreover, a combinatorial strategy integrating TA2O\u2010mediated photodynamic therapy with anti\u2010PD\u20101 immune checkpoint blockade (ICB) exhibits superior antitumor efficacy compared to either monotherapy. This immuno\u2010phototherapeutic approach represents a promising advance in precision cancer immunotherapy.<\/jats:p>","DOI":"10.1002\/anie.5265815","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:24:17Z","timestamp":1789097057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\u2010Activating Pyroptosis and cGAS\u2010STING Pathway for Immuno\u2010Photodynamic Therapy Based on a Thermally Activated Delayed Fluorescence Photosensitizer"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2235-8260","authenticated-orcid":false,"given":"Ruming","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Materials and Energy Foshan University  Foshan P. R. 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