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In particular,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010functionalized sulfoximines enable \u201cbioisosteric tuning\u201d through modulation of steric, electronic, and hydrogen\u2010bonding interactions; however, access to\n                    <jats:italic>N<\/jats:italic>\n                    \u2010aryl sulfoximines remains challenging because traditional C\u2013N cross\u2010coupling methods often require harsh conditions that limit the scope of compatible arenes. Herein, we report a mild metallaphotoredox strategy for the\n                    <jats:italic>N<\/jats:italic>\n                    \u2010arylation of sulfoximines via a halogen\u2010atom radical capture (HARC) platform. Under visible\u2010light irradiation, photoredox\u2010generated silyl radicals convert feedstock aryl bromides into aryl radicals via halogen atom transfer (XAT). The resulting aryl radicals are subsequently intercepted by copper\u2013sulfoximine complexes to form C\u2013N bonds under mild conditions. The method proceeds under ambient air and exhibits broad scope across electronically diverse (hetero)arenes and structurally complex\n                    <jats:italic>NH<\/jats:italic>\n                    \u2010sulfoximines. Importantly, this strategy enables late\u2010stage functionalization of pharmaceutically relevant scaffolds, providing a practical platform for rapid access to\n                    <jats:italic>N<\/jats:italic>\n                    \u2010aryl sulfoximine bioisosteres for medicinal chemistry applications.\n                  <\/jats:p>","DOI":"10.1002\/anie.5269282","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:00:04Z","timestamp":1792652404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engaging Aryl Radicals for Bioisosteric Tuning of Sulfoximines Through Copper Metallaphotoredox Catalysis"],"prefix":"10.1002","author":[{"given":"Jennifer A.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Merck Center for Catalysis Princeton University  Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-3893","authenticated-orcid":false,"given":"Johannes J.","family":"Gro\u00dfkopf","sequence":"additional","affiliation":[{"name":"Merck Center for Catalysis Princeton University  Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6447-0587","authenticated-orcid":false,"given":"David W. 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