{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T17:44:34Z","timestamp":1786211074442,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22578145"],"award-info":[{"award-number":["22578145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22278161"],"award-info":[{"award-number":["22278161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22378146"],"award-info":[{"award-number":["22378146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2025ZYGXZR035"],"award-info":[{"award-number":["2025ZYGXZR035"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,8,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Developing artificial antioxidases represents a promising strategy for treatment of oxidative\u2010stress\u2010related disorders; however, their practical application is often hindered by insufficient catalytic activity. Here, we report a dual\u2010cobalt coordinated phthalocyanine carboxylate derivative (biCoPc) as an efficient artificial antioxidase with markedly enhanced reactive oxygen species scavenging capability for the alleviation of inflammatory bowel disease (IBD). Experimental studies combined with theoretical calculations reveal that the extended \u03c0\u2010conjugation and \u03c0\u2010electron delocalization within the dimeric phthalocyanine framework, together with the protonation\u2010deprotonation dynamics of peripheral carboxyl groups, synergistically promote a potential proton\u2010coupled electron transfer process at the dual\u2010cobalt active sites. This architecture accelerates electron transfer kinetics and creates a favorable catalytic microenvironment. Consequently, biCoPc exhibits high catalytic superoxide dismutase\u2010like and glutathione peroxidase\u2010like activities, along with robust stability under harsh conditions. Notably, biCoPc demonstrates pronounced anti\u2010inflammatory efficacy, efficiently alleviating IBD symptoms at both the cellular level and animal models. This work provides mechanistic insights into the rational design of high\u2010performance artificial enzymes and broadens their potential for biomedical applications.<\/jats:p>","DOI":"10.1002\/anie.5317513","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:55:16Z","timestamp":1781157316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineering of Artificial Antioxidase Enables Boosted Catalytic Activity in Inflammatory Bowel Disease Alleviation"],"prefix":"10.1002","volume":"65","author":[{"given":"Niya","family":"Ta","sequence":"first","affiliation":[{"name":"Lab of Applied Biocatalysis, School of Food Science and Technology State Key Laboratory of Pulp and Paper Engineering South China University of Technology  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Lab of Applied Biocatalysis, School of Food Science and Technology State Key Laboratory of Pulp and Paper Engineering South China University of Technology  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[{"name":"Lab of Applied Biocatalysis, School of Food Science and Technology State Key Laboratory of Pulp and Paper Engineering South China University of Technology  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Du","sequence":"additional","affiliation":[{"name":"Lab of Applied Biocatalysis, School of Food Science and Technology State Key Laboratory of Pulp and Paper Engineering South China University of Technology  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8593-9292","authenticated-orcid":false,"given":"Lele","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0248-3196","authenticated-orcid":false,"given":"Xiaoling","family":"Wu","sequence":"additional","affiliation":[{"name":"Lab of Applied Biocatalysis, School of Food Science and Technology State Key Laboratory of Pulp and Paper Engineering South China University of Technology  Guangzhou Guangdong China"},{"name":"Guangdong Provincial Key Laboratory of Green Processing of Natural Products and Product Safety South China University of Technology  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-3446","authenticated-orcid":false,"given":"Wenyong","family":"Lou","sequence":"additional","affiliation":[{"name":"Lab of Applied Biocatalysis, School of Food Science and Technology State Key Laboratory of Pulp and Paper Engineering South China University of Technology  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010023\u201001512\u20107"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805052"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb2695"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu5571"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300988"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202504435"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202101804"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00720C"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00626"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.149451"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c07048"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202407046"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102250"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202307569"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202400838"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202411202"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302329"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202514915"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056179\u20100"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969\u20102126(03)00155\u20102"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01297A"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja034382v"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214202"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.synbio.2018.10.001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c06306"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022290\u20101"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057180\u20103"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1872-2067(23)64445-6"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202400855"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202403285"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00082a007"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386\u20101425(03)00275\u20100"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.142775"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202201455"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gee.2021.05.006"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2017.08.002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2016.02.026"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrs.5206"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TA10063K"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202370116"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207243"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202111322"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274\u2010023\u20105760\u20105"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01312"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.136029"},{"key":"e_1_2_8_47_1","first-page":"20210267","article-title":"Bioinspired Copper Single\u2010Atom Nanozyme as a Superoxide Dismutase\u2010Like Antioxidant for Sepsis Treatment","volume":"2","author":"Yang J.","year":"2022","journal-title":"Exploration (Beijing, China)"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c03119"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202007130"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c17358"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04134"},{"key":"e_1_2_8_52_1","first-page":"13869","article-title":"Unveiling the Mechanism of Alleviating Ischemia Reperfusion Injury via a Layered Double Hydroxide\u2010Based Nanozyme","volume":"15","author":"Ma X.","year":"2023","journal-title":"ACS Applied Materials Interfaces"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.105807"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201065074\u20107"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001346\u2010x"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.147048"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010019\u20100172\u20104"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.142940"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010019\u20100462\u20109"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.02.033"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b08785"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2025.08.011"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2065"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.05.014"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028497\u20100"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2018.10.004"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.5317513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.5317513","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.5317513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T17:27:54Z","timestamp":1786210074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.5317513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":65,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2026,8,10]]}},"alternative-id":["10.1002\/anie.5317513"],"URL":"https:\/\/doi.org\/10.1002\/anie.5317513","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"assertion":[{"value":"2026-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5317513"}}