{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:56:11Z","timestamp":1787270171580,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,7,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The direct carbonylation of unactivated C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500H bonds remains a fundamental challenge in synthesis. Herein, we report a photo\u2010flow strategy for the \u03b4\u2010C(sp\n                    <jats:sup>3<\/jats:sup>\n                    )\u2500H carbonylative lactonization of free alcohols using carbon monoxide. The transformation proceeds via photochemical generation of alkoxyl radicals, selective 1,5\u2010hydrogen atom transfer, CO trapping to form \u03b4\u2010acyl radicals, and a crucial radical\u2013polar crossover event that enables intramolecular cyclization to \u03b4\u2010lactones. The use of a strongly oxidizing acridinium photocatalyst is essential to promote acyl radical oxidation, distinguishing this manifold from conventional proton\u2010coupled electron transfer (PCET) or ligand\u2010to\u2010metal charge transfer (LMCT) pathways. Continuous\u2010flow conditions facilitate efficient gas\u2013liquid mass transfer and safe handling of CO, enabling short reaction times and scalability. The method tolerates diverse functional groups and provides direct access to structurally complex and bioactive \u03b4\u2010lactone motifs from simple alcohol feedstocks.\n                  <\/jats:p>","DOI":"10.1002\/anie.5570038","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:38:07Z","timestamp":1780058287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Direct \u03b4\u2010Lactone Synthesis From Free Alcohols via Photoinduced \u03b4\u2010C(sp\n                    <sup>3<\/sup>\n                    )\u2013H Carbonylation in Flow"],"prefix":"10.1002","volume":"65","author":[{"given":"Prakash Chandra","family":"Tiwari","sequence":"first","affiliation":[{"name":"Flow Chemistry Group Van \u2019t Hoff Institute for Molecular Sciences (HIMS) University of Amsterdam  Amsterdam the 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