{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:06:38Z","timestamp":1789110398619,"version":"build-2803163510"},"reference-count":81,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Natural pentamer dodecahedra (Ddhs) span six orders of magnitude in diameter. Among proteins, only two catalytic Ddhs have been structurally characterized: lumazine synthase (LS) and the core of pyruvate dehydrogenase (PDH). Zuzalysin (ZUZ) is a \u224895\u2010kDa metallopeptidase secreted for virulence by\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    . Calcium converts latent flexible monomers into active \u22480.5\u2010MDa pentamers that further assemble hierarchically into bipentamers, tripentamers, and a \u22485.6\u2010MDa, \u2248355\u2010\u00c5 virus\u2010like dodecahedron (Ddh\n                    <jats:sub>ZUZ<\/jats:sub>\n                    ). Experimental structures (1.8\u20133.6 \u00c5) across these states reveal the molecular basis of activation, association, and catalysis, culminating in Ddh\n                    <jats:sub>ZUZ<\/jats:sub>\n                    , which is physiologic, exceeds small viral capsids, and has 20 main entry pores and 60 lumen\u2010facing active sites. ZUZ represents the largest catalytic protein assembly resolved at high resolution, exceeding LS, PDH, and major peptidase complexes in size and\/or resolution.\n                  <\/jats:p>","DOI":"10.1002\/anie.5597279","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:28:39Z","timestamp":1789108119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structure and Function of a Multi\u2010Megadalton Virus\u2010Like Proteolytic Dodecahedron"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9935-3871","authenticated-orcid":false,"given":"Mariusz","family":"Madej","sequence":"first","affiliation":[{"name":"Department of Microbiology Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-0639","authenticated-orcid":false,"given":"Arturo","family":"Rodr\u00edguez\u2010Banqueri","sequence":"additional","affiliation":[{"name":"Proteolysis Laboratory Department of Structural Biology Barcelona Science Park Molecular Biology Institute of Barcelona (CSIC)  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1023-9384","authenticated-orcid":false,"given":"Danuta","family":"Mizgalska","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borys","family":"Szmigielski","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-7538","authenticated-orcid":false,"given":"Zuzanna","family":"Nowakowska","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5432-8739","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Benedyk\u2010Machaczka","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Bzowska","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-489X","authenticated-orcid":false,"given":"Katarzyna","family":"Mikruta","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University  Krak\u00f3w Poland"},{"name":"Doctoral School of Exact and Natural Sciences Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-209X","authenticated-orcid":false,"given":"Juan Sebasti\u00e1n","family":"Ram\u00edrez\u2010Larrota","sequence":"additional","affiliation":[{"name":"Proteolysis Laboratory Department of Structural Biology Barcelona Science Park Molecular Biology Institute of Barcelona (CSIC)  Barcelona Catalonia Spain"},{"name":"Synthetic Structural Biology Department of Structural Biology Barcelona Science Park Molecular Biology Institute of Barcelona (CSIC)  Barcelona Catalonia Spain"},{"name":"Graduate Program in Biotechnology Faculty of Pharmacy and Food Sciences University of Barcelona  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9895-7503","authenticated-orcid":false,"given":"Chinanu","family":"Agunanne","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences Center For Discovery and Innovation in Parasitic Diseases University of California Dan Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7068-7299","authenticated-orcid":false,"given":"Olivier","family":"Julien","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Alberta  Edmonton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5695-0409","authenticated-orcid":false,"given":"Anthony J.","family":"O'Donoghue","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences Center For Discovery and Innovation in Parasitic Diseases University of California Dan Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4304-0681","authenticated-orcid":false,"given":"Carsten","family":"Scavenius","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5496-9827","authenticated-orcid":false,"given":"Mario","family":"L\u00f3pez\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Synthetic Structural Biology Department of Structural Biology Barcelona Science Park Molecular Biology Institute of Barcelona (CSIC)  Barcelona Catalonia Spain"},{"name":"Protein Design and Modelling Laboratory Department of Structural Biology Molecular Biology Institute of Barcelona (CSIC) Barcelona Science Park  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8736-4082","authenticated-orcid":false,"given":"Enrique","family":"Marcos","sequence":"additional","affiliation":[{"name":"Protein Design and Modelling Laboratory Department of Structural Biology Molecular Biology Institute of Barcelona (CSIC) Barcelona Science Park  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-3845","authenticated-orcid":false,"given":"\u0141ukasz","family":"Koziej","sequence":"additional","affiliation":[{"name":"Ma\u0142opolska Centre of Biotechnology Jagiellonian University  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-7133","authenticated-orcid":false,"given":"Sebastian","family":"Glatt","sequence":"additional","affiliation":[{"name":"Ma\u0142opolska Centre of Biotechnology Jagiellonian University  Krak\u00f3w Poland"},{"name":"Department of Biological Sciences and Pathology University of Veterinary Medicine Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-3862","authenticated-orcid":false,"given":"Pablo","family":"Guerra","sequence":"additional","affiliation":[{"name":"Cryo\u2010Electron Microscopy Platform Molecular Biology Institute of Barcelona (CSIC) and Joint Electron Microscopy Centre at ALBA (JEMCA)  Cerdanyola del Vall\u00e8s Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-4514","authenticated-orcid":false,"given":"Ulrich","family":"Eckhard","sequence":"additional","affiliation":[{"name":"Synthetic Structural Biology Department of Structural Biology Barcelona Science Park Molecular Biology Institute of Barcelona (CSIC)  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Potempa","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University  Krak\u00f3w Poland"},{"name":"Department of Oral Immunology and Infectious Diseases University of Louisville School of Dentistry  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-6874","authenticated-orcid":false,"given":"F. Xavier","family":"Gomis\u2010R\u00fcth","sequence":"additional","affiliation":[{"name":"Proteolysis Laboratory Department of Structural Biology Barcelona Science Park Molecular Biology Institute of Barcelona (CSIC)  Barcelona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-51669-7_7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-51669-7_8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12070718"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09996"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35024037"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja049247c"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marmicro.2016.04.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01916122.2017.1298540"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2017.02.005"},{"key":"e_1_2_9_11_1","first-page":"1699","volume-title":"Report on the Scientific Results of the Voyage of H.M.S. Challenger During the Years 1873\u20131876., Vol. Zoology\u2013Vol. XVIII","author":"Haeckel E.","year":"1887"},{"key":"e_1_2_9_12_1","volume-title":"Report on the Scientific Results of the Voyage of H.M.S. Challenger During the Years 1873\u20131876., Vol. Zoology\u2013Vol. XVIII","author":"Haeckel E.","year":"1887"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01944"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070821"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800947-5.00002-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.11.041"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046075"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01033\u201012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01536\u201023"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2006.02.014"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01536\u201009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201007213\u20102"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.60.080805.142304"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10113"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.4.1240"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.563148"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adn4582"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12255"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20101033.1994.tb19079.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.52.33201"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.8.11.2355"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910029690"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910053370"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.10.006"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2019.46.10.907"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12915"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.18.5591\u20105601.2003"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2013.10.004"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2400"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3948"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20105793(93)80312\u2010I"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00030"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.4.1255\u20101263.1991"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003627"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.04.003"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2017.04.003"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2052252519013848"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3DT00458A"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109258(17)31914\u20102"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1385\/1\u201059259\u2010046\u20102:495"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u2010291X(67)80055\u2010X"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2011.04.014"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102958.2010.07434.x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-28849-4.00117-X"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.083378"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0896\u2010671"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4519"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/358164a0"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014\u20105793(00)02163\u20103"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2013.08.024"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.05.022"},{"key":"e_1_2_9_62_1","unstructured":"E.KrissinelandK.Henrick Computational Life Sciences: First International Symposium CompLife 2005 Konstanz (Germany) September 25\u201327 2005 (Conference Proceedings) ed.M. R.Berthold R.Glen K.Diederichs O.Kohlbacher andI.Fischer (Springer 2005) 163\u2013174 https:\/\/doi.org\/10.1007\/1156050010.1007\/11560500_15."},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.12.027"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010020\u20100716\u2010y"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312035200"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033698\u20108"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211076109"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2023839118"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033893\u20107"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.08.002"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010019\u201003338\u20104"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.247437"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.17.6878"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600031103"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20102836(03)00845\u20103"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/90380"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106807\u201012\u201014"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409455200"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.11.001"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.1999.4169"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/35106609"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1870"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.5597279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.5597279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.5597279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:28:41Z","timestamp":1789108121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.5597279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":81,"alternative-id":["10.1002\/anie.5597279"],"URL":"https:\/\/doi.org\/10.1002\/anie.5597279","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"2026-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5597279"}}