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Herein, we introduce a sono\u2010tribocatalytic vaccine platform by integrating MnVO\n                    <jats:sub>3<\/jats:sub>\n                    nanosheets into tumor cells, enabling ultrasound\u2010controlled immune boosting following a single vaccination. Upon a single subcutaneous injection, non\u2011invasive ultrasound irradiation triggers intense interfacial friction between the nanosheets and surrounding tissue fluids, driving efficient generation of reactive oxygen species via triboelectric charge transfer and concurrent release of metal ions that orchestrate metal\u2011immune crosstalk. This unique sono\u2011tribocatalytic process establishes a spatiotemporally remote control of localized inflammation to function as an on\u2010demand \u201csono\u2010booster.\u201d Mechanistically, this sono\u2010booster reprograms the local immune microenvironment by amplifying oxidative stress and inflammatory signaling, thereby promoting dendritic cell maturation and antigen cross\u2011presentation to elicit antigen\u2011specific T cell responses. Remarkably, a single dose of this sono\u2011tribocatalytic vaccine achieves potent anti\u2010tumor efficacy across multiple preclinical models. By enabling on\u2011demand, non\u2011invasive immune boosting from a single injection through a sono\u2011tribocatalytic mechanism, this vaccine platform establishes an externally controllable strategy for enhancing vaccine\u2010induced immunity and offers a versatile framework for next\u2010generation cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/anie.5688540","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:33:05Z","timestamp":1789183985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sono\u2010Tribocatalytic Whole Tumor Cell Vaccine Enables Ultrasound\u2010Controlled Immune Boosting for Enhanced Anti\u2010Tumor Immunity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7067-7813","authenticated-orcid":false,"given":"Hongze","family":"Ren","sequence":"first","affiliation":[{"name":"Materdicine Lab, School of Life Sciences 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