{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:17:07Z","timestamp":1783952227590,"version":"3.55.0"},"reference-count":69,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,7,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The confinement of paramagnetic centres to the internal channels of mesoporous nanoparticles brings with it a much greater contribution from outer sphere effects by virtue of tuneable side wall association and a resulting much stretched water diffusion coefficient. We specifically utilise the relative ease of side wall modifications to demonstrate that kosmotropic (water\u2010ordering) effects can be leveraged to greatly increase the viscosity of water in the vicinity of internalised paramagnetic complexes. This has the effect of supporting unprecedented levels of image contrast with\n                    <jats:italic>q<\/jats:italic>\n                    \u00a0=\u00a00 systems and much enhanced\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    contrast for common\n                    <jats:italic>q<\/jats:italic>\n                    \u00a0=\u00a01 complexes, at clinically relevant field strengths. Physiologically relevant potassium\u2010responsive imaging was subsequently enabled by modulating the water organisation initially imparted by internalised crown ethers on specific cation binding.\n                  <\/jats:p>","DOI":"10.1002\/anie.5723493","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T08:02:22Z","timestamp":1779264142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Slowing Down Water: Enhanced and Cation\u2010responsive MRI Contrast"],"prefix":"10.1002","volume":"65","author":[{"given":"Connor M.","family":"Ellis","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc E.","family":"M\u00f3zes","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research Radcliffe Department of Medicine University of Oxford, Level 0, John Radcliffe Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Faulkner","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2015.09.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000000567"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6385252"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0b013e31829c4686"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000184756.66360.d3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000132"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc44268c"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1845637"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185115590434"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/b504435a"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CC37545A"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB01894A"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2jm35116a"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC03312B"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13173795"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.1480"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00081a003"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b07959"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2021.120730"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099\u20100682(200003)2000:3<399::AID\u2010EJIC399>3.0.CO;2\u2010B"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.9b08667"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cp24075k"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.8b12204"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c00340"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp803234a"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521\u20103773(20020315)41:6<1017::AID\u2010ANIE1017>3.0.CO;2\u2010P"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3456987"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC01352F"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201300635"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c11342"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202200245"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.1c10162"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.0c02595"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1722263115"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CP01290D"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b02008"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00363"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/b510982p"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic00099a020"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201906539"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja900884j"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC00418J"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0528228"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201001615\u2010z"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20220004"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/b707225b"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja043567e"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2017.03.026"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41560\u2010017\u20100018\u20107"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1329"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2019.12.002"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja903340e"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202670"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c00596"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.200500250"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2996179"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp1112125"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC06255K"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201000499"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp991258i"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376\u20107388(98)00358\u20105"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214398"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SD00062H"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446268"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u20106175.2002.01728.x"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27951"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax9757"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010018\u20100269\u20102"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214150"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.5723493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.5723493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.5723493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:20:56Z","timestamp":1783948856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.5723493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":69,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2026,7,13]]}},"alternative-id":["10.1002\/anie.5723493"],"URL":"https:\/\/doi.org\/10.1002\/anie.5723493","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"assertion":[{"value":"2026-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5723493"}}