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However, such a transformation has remained underexplored to date, likely due to the inherently low reactivity of internal alkenes and the lack of suitable catalysts. In this study, we describe a lanthanum\u2010catalyzed highly regioselective C\u2500H alkylation of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010aryl pyrazoles with internal alkenes. The key to success of this unprecedented transformation is the use of a cationic imidazolin\u20102\u2010iminato lanthanum catalyst, whose large ionic radius and less steric hindrance provide an open coordination environment that facilitates the coordination of sterically demanding internal alkenes to the metal center and subsequent alkene migratory insertion. Besides internal alkenes, 1,1\u2010disubstituted styrenes and terminal alkenes were amenable to the reaction. This protocol offers a straightforward and atom\u2010efficient route for the synthesis of a new family of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010((\n                    <jats:italic>ortho\u2010<\/jats:italic>\n                    alkyl)aryl) pyrazole derivatives (94 examples, up to 99% yield, &gt;19:1 rr). The scale\u2010up synthesis and further transformation to hedgehog enzyme inhibitor analog highlight the potential application of this method. Combined experimental and computational studies elucidated the reaction mechanism and the influence of metal ion size on the turnover\u2010limiting alkene migratory insertion step.\n                  <\/jats:p>","DOI":"10.1002\/anie.5737595","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:33:06Z","timestamp":1787812386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regioselective Hydroarylation of Internal and Terminal Alkenes With\n                    <i>N<\/i>\n                    \u2010Aryl Pyrazoles Enabled by Lanthanum Catalysts"],"prefix":"10.1002","author":[{"given":"Shiyu","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology Ministry of Education College of Chemistry Sichuan University Chengdu China"},{"name":"Hubei Key Laboratory of Pollutant Analysis &amp; Reuse Technology College of Chemistry and 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