{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:04:45Z","timestamp":1789617885819,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Enolized homoenolates have emerged as distinct intermediates in cyclopropanol chemistry, enabling bond constructions beyond classical homoenolate and \u03b2\u2010keto radical manifolds. Their reactions with intrinsically electrophilic partners are established, but interception by catalytically generated electrophiles has remained unexplored. Herein, we report a palladium\u2010catalyzed, zinc\u2010mediated formal \u201callylic cyclopropylation\u201d of cyclopropanols with allyl acetates. The reaction installs diverse allyl groups through transient ring opening to an enolized homoenolate, interception by \u03c0\u2010allylpalladium, and ring closure, thereby preserving the cyclopropane framework. An enantioselective variant, particularly effective for bicyclic substrates, demonstrates stereochemical control over these transient intermediates. Stereochemical experiments support a double\u2010inversion pathway characteristic of Tsuji\u2013Trost reactivity. These findings integrate enolized homoenolates with transition\u2010metal catalysis and expand the scope of ring\u2010retentive cyclopropanol functionalization.<\/jats:p>","DOI":"10.1002\/anie.5796773","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:42:09Z","timestamp":1789616529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ring\u2010Retentive Allylation of Cyclopropanols Through Interception of Enolized Homoenolates by \u03c0\u2010Allylpalladium"],"prefix":"10.1002","author":[{"given":"Kento","family":"Tsukiji","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"Miura","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Tohoku University  Sendai 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