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Here we introduce a rapid and scalable strategy for AMP identification that integrates low\u2010cost, self\u2010assembled polydiacetylene (PDA) sensors with hyperspectral imaging and deep learning. AMP\u2013PDA interactions generate mechanochromic spectral fingerprints that capture subtle differences in affinity, conformation, and penetration depth in membranes. Convolutional neural networks (CNNs) trained on full spectral datasets accurately distinguished seven AMPs at two concentrations with 96.79% accuracy, whereas conventional two\u2010wavelength colorimetric response failed entirely. The rich chemical information embedded across the entire visible wavelength spectral region reveals that mechanochromic polymers encode far more detail than previously recognized. These findings establish PDA mechanochromism, when paired with high\u2010throughput spectral imaging and deep learning, as a powerful and accessible platform for rapid AMP screening and, more broadly, as a foundation for scalable, information\u2010dense biosensing technologies.<\/jats:p>","DOI":"10.1002\/anie.5828776","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:38:27Z","timestamp":1783676307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep Learning Enables Identification of Antimicrobial Peptides Through Mechanochromic Fingerprints"],"prefix":"10.1002","volume":"65","author":[{"given":"Jiali","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Industrial Science The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che\u2010Lun","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzhen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Industrial Science The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3512-6036","authenticated-orcid":false,"given":"Kaori","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Institute of Industrial Science The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167\u20107799(97)01156\u20106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010025\u201001200\u2010y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau5480"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779\u2010021\u201000343\u20102"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c04027"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c01433"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.5c00085"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00418a026"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35073544"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.4c03300"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.0c00718"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202300745"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201200819"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/72697"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.1c07533"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095\u2010006\u20109569\u20101"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC06803F"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/B820894H"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SM02579J"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mren.202400016"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi800335e"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034\u20104257(88)90012\u20100"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4736"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055774\u2010x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1989.1.4.541"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.4c03260"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/s19071714"},{"key":"e_1_2_9_29_1","unstructured":"M. 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