{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:59:22Z","timestamp":1790654362567,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22171190"],"award-info":[{"award-number":["22171190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    (\u2212)\u2010Penostatin G, isolated from the marine green alga\n                    <jats:italic>Enteromorpha intestinalis<\/jats:italic>\n                    , has an interesting tetracyclic structure and potent anticancer activity. Herein, the total synthesis of (\u2212)\u2010penostatin G and its conversion to (\u2013)\u2010penostatins B and C are achieved for the first time. Our strategy for construction of the distinctive tetracyclic skeleton of penostatin G features a chiral exocyclic enone\u2010induced\n                    <jats:italic>exo<\/jats:italic>\n                    Diels\u2013Alder reaction, an MMPP\u2010mediated chemo\u2010 and regioselective Baeyer\u2013Villiger oxidation, and an intramolecular oxa\u2010Diels\u2013Alder reaction of the cyclic vicinal tricarbonyl precursor with high stereoselectivity. By the protection\u2010free approach, penostatin G was synthesized from the commercial substituted cyclopentanone in 12 longest linear steps.\n                  <\/jats:p>","DOI":"10.1002\/anie.5853261","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:51:18Z","timestamp":1790653878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Total Synthesis of (\u2013)\u2010Penostatins G, B and C Featuring an Intramolecular oxa\u2010Diels\u2013Alder Reaction of a Cyclic Tricarbonyl Precursor"],"prefix":"10.1002","author":[{"given":"Zupei","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education, College of Chemistry Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Xiong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education, College of Chemistry Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanliang","family":"Jia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education, College of Chemistry Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folei","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education, College of Chemistry Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leijie","family":"Fu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education, College of Chemistry Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education, College of Chemistry Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3901-0524","authenticated-orcid":false,"given":"Xiaochuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education, College of Chemistry Sichuan University  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040\u20104039(95)02225\u20102"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/a706853k"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0040\u20104020(99)00884\u20104"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19021663"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2022.2104719"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.1c00248"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo982149n"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo000850x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol049680r"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol3019488"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol203021c"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo501225y"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo502101u"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c01649"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c00485"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4ob01186d"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c00931"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202501050"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b00632"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b02470"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo071146k"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/b924577d"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b01502"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b09974"},{"key":"e_1_2_8_26_1","unstructured":"Deposition numbers 2514417 (for8) contain the supplementary crystallographic data for this paper. 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